КФУ. Карточка публикации. Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase

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SCHWANN CELLS SENSE AND CONTROL ACETYLCHOLINE SPILLOVER AT THE NEUROMUSCULAR JUNCTION BY A7 NICOTINIC RECEPTORS AND BUTYRYLCHOLINESTERASE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Язык

английский

Авторы, сотрудники КФУ

Никольский Евгений Евгеньевич, автор

Нуруллин Лениз Фаритович, автор

Петров Константин Александрович, автор

Самигуллин Дмитрий Владимирович, автор

Библиографическое описание на языке оригинала

Petrov K.A. Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase / K.A. Petrov, E. Girard, A.D. Nikitashina, C. Colasante, V. Bernard, L. Nurullin, J. Leroy, D. Samigullin, O. Colak, E. Nikolsky, B. Plaud, E. Krejci //Journal of Neuroscience. - 2014. - Vol.34, Is.36. - P.11870-11883.

Аннотация

Terminal Schwann cells (TSCs) are key components of the mammalian neuromuscular junction (NMJ). How the TSCs sense the synaptic activity in physiological conditions remains unclear. We have taken advantage of the distinct localization of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at the NMJ to bring out the function of different ACh receptors (AChRs). AChE is clustered by the collagen Q in the synaptic cleft and prevents the repetitive activation of muscle nicotinic AChRs. We found that BChE is anchored at the TSC. When BChE was specifically inhibited, ACh release was significant depressed through the activation of α7 nAChRs localized on the TSC and activated by the spillover of ACh. When both AChE and BChE were inhibited, the spillover increased and induced a dramatic reduction of ACh release that compromised the muscle twitch triggered by the nerve stimulation.

Ключевые слова

acetylcholinesterase, glia, muscle, neuromuscular disease, synaptic homeostasis

Название журнала

Journal of Neuroscience

URL

http://www.scopus.com/inward/record.url?eid=2-s2.0-84906901943&partnerID=40&md5=1a03b9a520c81afc117597f8a45221c4

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https://repository.kpfu.ru/?p_id=135860

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Никольский Евгений Евгеньевич	ru_RU
dc.contributor.author	Нуруллин Лениз Фаритович	ru_RU
dc.contributor.author	Петров Константин Александрович	ru_RU
dc.contributor.author	Самигуллин Дмитрий Владимирович	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Petrov K.A. Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase / K.A. Petrov, E. Girard, A.D. Nikitashina, C. Colasante, V. Bernard, L. Nurullin, J. Leroy, D. Samigullin, O. Colak, E. Nikolsky, B. Plaud, E. Krejci //Journal of Neuroscience. - 2014. - Vol.34, Is.36. - P.11870-11883.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=135860	ru_RU
dc.description.abstract	Journal of Neuroscience	ru_RU
dc.description.abstract	Terminal Schwann cells (TSCs) are key components of the mammalian neuromuscular junction (NMJ). How the TSCs sense the synaptic activity in physiological conditions remains unclear. We have taken advantage of the distinct localization of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at the NMJ to bring out the function of different ACh receptors (AChRs). AChE is clustered by the collagen Q in the synaptic cleft and prevents the repetitive activation of muscle nicotinic AChRs. We found that BChE is anchored at the TSC. When BChE was specifically inhibited, ACh release was significant depressed through the activation of α7 nAChRs localized on the TSC and activated by the spillover of ACh. When both AChE and BChE were inhibited, the spillover increased and induced a dramatic reduction of ACh release that compromised the muscle twitch triggered by the nerve stimulation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acetylcholinesterase	ru_RU
dc.subject	glia	ru_RU
dc.subject	muscle	ru_RU
dc.subject	neuromuscular disease	ru_RU
dc.subject	synaptic homeostasis	ru_RU
dc.title	Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU