КФУ. Карточка публикации. Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-

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SENSING ACTIVITY OF CHOLINESTERASES THROUGH A LUMINESCENCE RESPONSE OF THE HEXARHENIUM CLUSTER COMPLEX [{RE6S8}(OH)6]4-

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Массон Патрик Ивон Морис , автор

Петров Константин Александрович, автор

Библиографическое описание на языке оригинала

Elistratova J.G. Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-/ J.G. Elistratova, A.R. Mustafina,K .A. Brylev, K.A. Petrov, M.A. Shestopalov, Y.V. Mironov, V.M. Babaev, I.K. Rizvanov, P. Masson, O.G. Sinyashin // Analyst. - 2016. - Vol.141, Is.13. - P.4204-4210.

Аннотация

he present work describes a new method to sense cholinesterase-catalyzed hydrolysis of acetylcholine (ACh) through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-. A proton released from acetylcholinesterase (AChE)- or butyrylcholinesterase (BuChE)-catalyzed hydrolysis of ACh results in time-resolved sensitization of cluster-centered luminescence. The sensitization results from protonation of apical hydroxo-groups of the cluster complex. The protonation is affected by a counter ion effect. Thus, optimal conditions for adequate sensing of acetic acid produced by ACh hydrolysis are highlighted. Time-resolved luminescence and pH measurements under conditions of AChE-catalyzed hydrolysis of ACh show a good correlation between the cluster-centered luminescence and pH-induced inhibition of AChE. The inhibition is not significant within the first two minutes of ACh hydrolysis. Thus, the luminescence response measured within two minutes is dependent on both substrat

Ключевые слова

Acetylcholinesterase, hexarhenium cluster complex [{Re6S8}(OH)6]4-

Название журнала

Analyst

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976448483&partnerID=40&md5=1719df423c629316604f5ec2a11a75cd

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https://repository.kpfu.ru/?p_id=136571

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Массон Патрик Ивон Морис	ru_RU
dc.contributor.author	Петров Константин Александрович	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Elistratova J.G. Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-/ J.G. Elistratova, A.R. Mustafina,K .A. Brylev, K.A. Petrov, M.A. Shestopalov, Y.V. Mironov, V.M. Babaev, I.K. Rizvanov, P. Masson, O.G. Sinyashin // Analyst. - 2016. - Vol.141, Is.13. - P.4204-4210.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=136571	ru_RU
dc.description.abstract	Analyst	ru_RU
dc.description.abstract	he present work describes a new method to sense cholinesterase-catalyzed hydrolysis of acetylcholine (ACh) through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-. A proton released from acetylcholinesterase (AChE)- or butyrylcholinesterase (BuChE)-catalyzed hydrolysis of ACh results in time-resolved sensitization of cluster-centered luminescence. The sensitization results from protonation of apical hydroxo-groups of the cluster complex. The protonation is affected by a counter ion effect. Thus, optimal conditions for adequate sensing of acetic acid produced by ACh hydrolysis are highlighted. Time-resolved luminescence and pH measurements under conditions of AChE-catalyzed hydrolysis of ACh show a good correlation between the cluster-centered luminescence and pH-induced inhibition of AChE. The inhibition is not significant within the first two minutes of ACh hydrolysis. Thus, the luminescence response measured within two minutes is dependent on both substrat	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acetylcholinesterase	ru_RU
dc.subject	hexarhenium cluster complex [{Re6S8}(OH)6]4-	ru_RU
dc.title	Sensing activity of cholinesterases through a luminescence response of the hexarhenium cluster complex [{Re6S8}(OH)6]4-	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU