КФУ. Карточка публикации. 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms

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2(5H)-FURANONE DERIVATIVES AS INHIBITORS OF STAPHYLOCOCCAL BIOFILMS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Каюмов Айрат Рашитович, автор

Курбангалиева Альмира Рафаэловна, автор

Латыпова Лилия Зиннуровна, автор

Тризна Елена Юрьевна, автор

Другие авторы

Богачев Михаил Игоревич, автор

Авторы, аспиранты КФУ

Тризна Елена Юрьевна, автор

Библиографическое описание на языке оригинала

Trizna E. 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms / E. Trizna, L. Latypova, A. Kurbangalieva, M. Bogachev, A. Kayumov // BioNanoScience. - 2016. DOI: 10.1007/s12668-016-0258-1.

Аннотация

The opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on wounds and artificial surfaces and thereby become extremely resistant to antimicrobials. Here, we report the effect of four novel 2(5H)-furanone derivatives on the cell growth and biofilm formation by these microorganisms. Using the differential fluorescence staining of viable and dead cells, we demonstrated that furanones increase the antibacterial efficacy of chloramphenicol against both biofilm-embedded S. aureus and S. epidermidis with F35 being the most efficient compound, probably by increasing the accessibility of cells against antimicrobials. Compounds F6, F8, and F83 inhibited the biofilm formation at concentrations of 2.5–10 μg/ml, although exhibiting high cytotoxicity for human skin fibroblasts with CC50 of 0.5–1.1 μg/ml. F35 demonstrated minimal biofilm inhibition concentration of 10 μg/ml, while its cytotoxicity was ten times lower than that of the other compounds (

Ключевые слова

Antibacterial activity, Biofilms, S. aureus, S. epidermidis, 2(5H)-furanones, Unsaturated lactones

Название журнала

BioNanoScience

URL

https://www.researchgate.net/publication/307555580_25H-Furanone_Derivatives_as_Inhibitors_of_Staphylococcal_Biofilms

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https://repository.kpfu.ru/?p_id=138242

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Каюмов Айрат Рашитович	ru_RU
dc.contributor.author	Курбангалиева Альмира Рафаэловна	ru_RU
dc.contributor.author	Латыпова Лилия Зиннуровна	ru_RU
dc.contributor.author	Тризна Елена Юрьевна	ru_RU
dc.contributor.author	Богачев Михаил Игоревич	ru_RU
dc.contributor.author	Тризна Елена Юрьевна	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Trizna E. 2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms / E. Trizna, L. Latypova, A. Kurbangalieva, M. Bogachev, A. Kayumov // BioNanoScience. - 2016. DOI: 10.1007/s12668-016-0258-1.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=138242	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The opportunistic bacteria Staphylococcus aureus and Staphylococcus epidermidis often form rigid biofilms on wounds and artificial surfaces and thereby become extremely resistant to antimicrobials. Here, we report the effect of four novel 2(5H)-furanone derivatives on the cell growth and biofilm formation by these microorganisms. Using the differential fluorescence staining of viable and dead cells, we demonstrated that furanones increase the antibacterial efficacy of chloramphenicol against both biofilm-embedded S. aureus and S. epidermidis with F35 being the most efficient compound, probably by increasing the accessibility of cells against antimicrobials. Compounds F6, F8, and F83 inhibited the biofilm formation at concentrations of 2.5–10 μg/ml, although exhibiting high cytotoxicity for human skin fibroblasts with CC50 of 0.5–1.1 μg/ml. F35 demonstrated minimal biofilm inhibition concentration of 10 μg/ml, while its cytotoxicity was ten times lower than that of the other compounds (	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Antibacterial activity	ru_RU
dc.subject	Biofilms	ru_RU
dc.subject	S. aureus	ru_RU
dc.subject	S. epidermidis	ru_RU
dc.subject	2(5H)-furanones	ru_RU
dc.subject	Unsaturated lactones	ru_RU
dc.title	2(5H)-Furanone Derivatives as Inhibitors of Staphylococcal Biofilms	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU