| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2016 |
| Язык | английский |
|
Салахиева Диана Витальевна, автор
|
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Chen, Sadreev, Umezawa, Welsh, Kotov Michael, Ildar, Yoshinori, Gavin, Nikolay , автор
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| Библиографическое описание на языке оригинала |
Kinetic regulation of multi-ligand binding proteins. D.V. Salakhieva, I.I. Sadreev, M.Z.Q. Chen, Y. Umezawa, A.I. Evstifeev, G.I. Welsh, N.V. Kotov // BMC Systems Biology (2016) 10:32. DOI 10.1186/s12918-016-0277-0 |
| Аннотация |
In this study, a computational analysis of multisite protein kinetics in response to rapid changes in ligand concentrations is presented. Two major physiological scenarios are investigated: i) Ligand concentration is abundant and the ligand-multisite protein binding does not affect free ligand concentration, ii) Ligand concentration is of the same order of magnitude as the interacting multisite protein concentration and does
not change. Therefore, buffering effects significantly influence the amounts of free ligands. For each of these scenarios the influence of the number of binding sites, the temporal effects on intermediate apo- and fully saturated conformations and the multisite regulatory effects on target proteins are investigated. |
| Ключевые слова |
Ligand-receptor binding, transient kinetics, calcium, calmodulin. |
| Название журнала |
BMC Syst. Biol.
|
| URL |
http://doi:10.1186/s12918-016-0277-0 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=139051 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Салахиева Диана Витальевна |
ru_RU |
| dc.contributor.author |
Chen, Sadreev, Umezawa, Welsh, Kotov Michael, Ildar, Yoshinori, Gavin, Nikolay |
ru_RU |
| dc.date.accessioned |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2016-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2016 |
ru_RU |
| dc.identifier.citation |
Kinetic regulation of multi-ligand binding proteins. D.V. Salakhieva, I.I. Sadreev, M.Z.Q. Chen, Y. Umezawa, A.I. Evstifeev, G.I. Welsh, N.V. Kotov // BMC Systems Biology (2016) 10:32. DOI 10.1186/s12918-016-0277-0 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=139051 |
ru_RU |
| dc.description.abstract |
BMC Syst. Biol. |
ru_RU |
| dc.description.abstract |
In this study, a computational analysis of multisite protein kinetics in response to rapid changes in ligand concentrations is presented. Two major physiological scenarios are investigated: i) Ligand concentration is abundant and the ligand-multisite protein binding does not affect free ligand concentration, ii) Ligand concentration is of the same order of magnitude as the interacting multisite protein concentration and does
not change. Therefore, buffering effects significantly influence the amounts of free ligands. For each of these scenarios the influence of the number of binding sites, the temporal effects on intermediate apo- and fully saturated conformations and the multisite regulatory effects on target proteins are investigated. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Ligand-receptor binding |
ru_RU |
| dc.subject |
transient kinetics |
ru_RU |
| dc.subject |
calcium |
ru_RU |
| dc.subject |
calmodulin. |
ru_RU |
| dc.title |
Kinetic regulation of multi-ligand binding proteins |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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