КФУ. Карточка публикации. Propoxylation of cationic polymers provides a novel approach to controllable modulation of their cellular toxicity and interaction with nucleic acids

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PROPOXYLATION OF CATIONIC POLYMERS PROVIDES A NOVEL APPROACH TO CONTROLLABLE MODULATION OF THEIR CELLULAR TOXICITY AND INTERACTION WITH NUCLEIC ACIDS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Абдуллин Тимур Илдарович, автор

Бадеев Юрий Владимирович, автор

Салахиева Диана Витальевна, автор

Шевченко Веста Денисовна, автор

Штырлин Юрий Григорьевич, автор

Библиографическое описание на языке оригинала

Propoxylation of cationic polymers provides a novel approach to controllable modulation of their cellular toxicity and interaction with nucleic acids. Vesta D. Shevchenko, Diana V. Salakhieva, Abdulla A. Yergeshov, Yuriy V. Badeev, Yurii G. Shtyrlin, Timur I. Abdullin //Materials Science and Engineering C 69 (2016) 60–67.

Аннотация

An effective chemical approach to modulation of biological interactions of cationic polymers was proposed and tested using polyethyleneimine (PEI) as a drug carrier. Branched 25 kDa PEI was modified in the reaction with propylene oxide (PO) to produce a series of propoxylated PEIs with NH groups grafted by single or oligomer PO units. Clear relationships between the propoxylation degree and biological effects, such as interaction with plasmid DNA, hemolytic, cytotoxic, and pro-apoptotic activities were revealed for PEIs modified upon PO / NH molar ratio of 0.5, 0.75, 1.0 and 3.0. The partial modification of available cationic centers up to 100 % is predominantly accompanied by a significant gradual reduction in polycation adverse effects, while ability of complex formation with plasmid DNA is being preserved. Grafted PEI with 0.75 PO / NH ratio provides better protection from nuclease degradation and transfection activity compared with other modified PEIs.

Ключевые слова

Cationic polymers; Polyethyleneimine; Propoxylation; Biocompatibility; Cellular toxicity; Gene delivery

Название журнала

Materials Science & Engineering C

URL

http://dx.doi.org/10.1016/j.msec.2016.05.024

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https://repository.kpfu.ru/?p_id=139057

Файлы ресурса

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_MSEC_PEIs_PO_2016_article.pdf	0,96	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Абдуллин Тимур Илдарович	ru_RU
dc.contributor.author	Бадеев Юрий Владимирович	ru_RU
dc.contributor.author	Салахиева Диана Витальевна	ru_RU
dc.contributor.author	Шевченко Веста Денисовна	ru_RU
dc.contributor.author	Штырлин Юрий Григорьевич	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Propoxylation of cationic polymers provides a novel approach to controllable modulation of their cellular toxicity and interaction with nucleic acids. Vesta D. Shevchenko, Diana V. Salakhieva, Abdulla A. Yergeshov, Yuriy V. Badeev, Yurii G. Shtyrlin, Timur I. Abdullin //Materials Science and Engineering C 69 (2016) 60–67.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=139057	ru_RU
dc.description.abstract	Materials Science & Engineering C	ru_RU
dc.description.abstract	An effective chemical approach to modulation of biological interactions of cationic polymers was proposed and tested using polyethyleneimine (PEI) as a drug carrier. Branched 25 kDa PEI was modified in the reaction with propylene oxide (PO) to produce a series of propoxylated PEIs with NH groups grafted by single or oligomer PO units. Clear relationships between the propoxylation degree and biological effects, such as interaction with plasmid DNA, hemolytic, cytotoxic, and pro-apoptotic activities were revealed for PEIs modified upon PO / NH molar ratio of 0.5, 0.75, 1.0 and 3.0. The partial modification of available cationic centers up to 100 % is predominantly accompanied by a significant gradual reduction in polycation adverse effects, while ability of complex formation with plasmid DNA is being preserved. Grafted PEI with 0.75 PO / NH ratio provides better protection from nuclease degradation and transfection activity compared with other modified PEIs.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Propoxylation of cationic polymers provides a novel approach to controllable modulation of their cellular toxicity and interaction with nucleic acids	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU