КФУ. Карточка публикации. Amphiphilic calixresorcinarene associates as eﬀective solubilizing agents for hydrophobic organic acids: construction of nano-aggregates

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AMPHIPHILIC CALIXRESORCINARENE ASSOCIATES AS EﬀECTIVE SOLUBILIZING AGENTS FOR HYDROPHOBIC ORGANIC ACIDS: CONSTRUCTION OF NANO-AGGREGATES

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Коновалов Александр Иванович, автор

Морозова Юлия Эрнестовна, автор

Шалаева Яна Викторовна, автор

Другие авторы

Волошина Александра Дмитриевна, автор

Кадиров Марсил Кахирович, автор

Казакова Элла Хатибовна, автор

Низамеев Ирек Рашатович, автор

Сякаев Виктор Васильевич, автор

Библиографическое описание на языке оригинала

Ju. E. Morozova, Amphiphilic calixresorcinarene associates as eﬀective solubilizing agents for hydrophobic organic acids: construction of nano-aggregates / Ju. E. Morozova, V. V. Syakaev, E. Kh. Kazakova, Ya. V. Shalaeva, I. R. Nizameev, M. K. Kadirov, A. D. Voloshina, V. V. Zobov, A. I. Konovalov. // Soft Matter, 2016, 12, 5590 – 5599.

Аннотация

Here we represent the first example of the formation of mixed nanoscale associates, constructed from amphiphilic calixresorcinarenes and hydrophobic carboxylic acids including drugs. The amidoamino-calixresorcinarene self-associates eﬀectively solubilize hydrophobic carboxylic acids – drugs such as naproxen, ibuprofen, ursodeoxycholic acid and aliphatic dodecanoic acid – with the formation of the mixed aggregates with the macrocycle/substrate stoichiometry from 1/1 to 1/7. The ionization of organic acids and the peripheral nitrogen atoms of the macrocycles with the subsequent inclusion of hydrophobic acids into the macrocycle self-associates is the driving force of solubilization. In some cases, this leads to the co-assembly of the macrocycle polydisperse associates into supramolecular monodisperse nanoparticles with the diameter of about 100 nm. The efficiency of drug loading into the nanoparticles is up to 45% and depends on the structure of organic acid.

Ключевые слова

amphiphilic calixresorcinarenes, nanoscale associates, solubilization, hydrophobic drugs

Название журнала

SOFT MATTER

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https://repository.kpfu.ru/?p_id=139087

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Коновалов Александр Иванович	ru_RU
dc.contributor.author	Морозова Юлия Эрнестовна	ru_RU
dc.contributor.author	Шалаева Яна Викторовна	ru_RU
dc.contributor.author	Волошина Александра Дмитриевна	ru_RU
dc.contributor.author	Кадиров Марсил Кахирович	ru_RU
dc.contributor.author	Казакова Элла Хатибовна	ru_RU
dc.contributor.author	Низамеев Ирек Рашатович	ru_RU
dc.contributor.author	Сякаев Виктор Васильевич	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Ju. E. Morozova, Amphiphilic calixresorcinarene associates as eﬀective solubilizing agents for hydrophobic organic acids: construction of nano-aggregates / Ju. E. Morozova, V. V. Syakaev, E. Kh. Kazakova, Ya. V. Shalaeva, I. R. Nizameev, M. K. Kadirov, A. D. Voloshina, V. V. Zobov, A. I. Konovalov. // Soft Matter, 2016, 12, 5590 – 5599.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=139087	ru_RU
dc.description.abstract	SOFT MATTER	ru_RU
dc.description.abstract	Here we represent the first example of the formation of mixed nanoscale associates, constructed from amphiphilic calixresorcinarenes and hydrophobic carboxylic acids including drugs. The amidoamino-calixresorcinarene self-associates eﬀectively solubilize hydrophobic carboxylic acids – drugs such as naproxen, ibuprofen, ursodeoxycholic acid and aliphatic dodecanoic acid – with the formation of the mixed aggregates with the macrocycle/substrate stoichiometry from 1/1 to 1/7. The ionization of organic acids and the peripheral nitrogen atoms of the macrocycles with the subsequent inclusion of hydrophobic acids into the macrocycle self-associates is the driving force of solubilization. In some cases, this leads to the co-assembly of the macrocycle polydisperse associates into supramolecular monodisperse nanoparticles with the diameter of about 100 nm. The efficiency of drug loading into the nanoparticles is up to 45% and depends on the structure of organic acid.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	amphiphilic calixresorcinarenes	ru_RU
dc.subject	nanoscale associates	ru_RU
dc.subject	solubilization	ru_RU
dc.subject	hydrophobic drugs	ru_RU
dc.title	Amphiphilic calixresorcinarene associates as eﬀective solubilizing agents for hydrophobic organic acids: construction of nano-aggregates	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU