КФУ. Карточка публикации. Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy

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AMMONIA-INDUCED SENESCENCE IN CULTURED RAT ASTROCYTES AND IN HUMAN CEREBRAL CORTEX IN HEPATIC ENCEPHALOPATHY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Язык

английский

Авторы, сотрудники КФУ

Шафигуллина Айгуль Касыймовна, автор

Другие авторы

Bidmon Hans J. , автор

Görg Boris , автор

Häussinger Dieter , автор

Karababa Ayse , автор

Библиографическое описание на языке оригинала

Görg, B. Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy / B. Görg, A. Karababa, A. Shafigullina, H.J. Bidmon, D. Häussinger // Glia. – 2015. – Vol. 63. - № 1. – P. 37-50.

Аннотация

Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is due to a low-grade cerebral edema associated with oxidative/nitrosative stress. Recent reports suggest that cognitive impairment in cirrhotic patients may not resolve completely after an attack of manifest HE. As astrocyte dysfunction is central to the pathogenesis of HE and astrocytes are critically involved in synaptic plasticity, we tested for sustained impairment of astrocyte function by analyzing expression levels of senescence biomarkers in ammonia-treated cultured rat astrocytes and in postmortem brain samples from cirrhotic patients with or without HE. NH4 Cl time- and dose-dependently inhibited proliferation of cultured astrocytes by up to 45% (5 mmol/L, 72 h) and strongly increased senescence-associated β-galactosidase activity. Inhibition of astrocyte proliferation by ammonia was mediated by a l-methionine sulfoximine-, oxidative stress-, and p38(MAPK) -dependent activation of p53 associated wit

Ключевые слова

ammonia; astrocytes; glutamine; senescence

Название журнала

Glia

Ссылка для РПД

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/108583/Ammonia_induced_senescence__Goerg__2015.pdf?sequence=1&isAllowed=y

URL

https://www.ncbi.nlm.nih.gov/pubmed/25092802

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https://repository.kpfu.ru/?p_id=148264

Файлы ресурса

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Шафигуллина Айгуль Касыймовна	ru_RU
dc.contributor.author	Bidmon Hans J.	ru_RU
dc.contributor.author	Görg Boris	ru_RU
dc.contributor.author	Görg Boris	ru_RU
dc.contributor.author	Häussinger Dieter	ru_RU
dc.contributor.author	Karababa Ayse	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Görg, B. Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy / B. Görg, A. Karababa, A. Shafigullina, H.J. Bidmon, D. Häussinger // Glia. – 2015. – Vol. 63. - № 1. – P. 37-50.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=148264	ru_RU
dc.description.abstract	Glia	ru_RU
dc.description.abstract	Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is due to a low-grade cerebral edema associated with oxidative/nitrosative stress. Recent reports suggest that cognitive impairment in cirrhotic patients may not resolve completely after an attack of manifest HE. As astrocyte dysfunction is central to the pathogenesis of HE and astrocytes are critically involved in synaptic plasticity, we tested for sustained impairment of astrocyte function by analyzing expression levels of senescence biomarkers in ammonia-treated cultured rat astrocytes and in postmortem brain samples from cirrhotic patients with or without HE. NH4 Cl time- and dose-dependently inhibited proliferation of cultured astrocytes by up to 45% (5 mmol/L, 72 h) and strongly increased senescence-associated β-galactosidase activity. Inhibition of astrocyte proliferation by ammonia was mediated by a l-methionine sulfoximine-, oxidative stress-, and p38(MAPK) -dependent activation of p53 associated wit	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU