КФУ. Карточка публикации. NMR Studies of the Mn2+ Interactions with Amyloid Peptide Aβ13-23 in Water Environment

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NMR STUDIES OF THE MN2+ INTERACTIONS WITH AMYLOID PEPTIDE Aβ13-23 IN WATER ENVIRONMENT

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Авторы, сотрудники КФУ

Каратаева Фарида Хайдаровна, автор

Клочков Владимир Васильевич, автор

Усачев Константин Сергеевич, автор

Авторы, аспиранты КФУ

Абдрахманов Рустам Жамилевич, автор

Библиографическое описание на языке оригинала

Binding of Mn2+ ions to the fragment of beta-amyloid peptide (Aβ13-23) was studied. Manganese complexation induces important structural changes within the C-terminal segment of the peptide. Investigation of peptide Ab metal ion binding was made by MnCl2 salt titration and recording 2D 1H-1H NMR TOCSY spectra (TOtal Correlation SpectroscopY). Multidimensional NMR techniques were performed to understand the details of the conformational behavior of the peptide and to reveal the metalbinding sites. According to changes in NMR spectra, the manganese-binding center of the Aβ13-23 peptide is associated with the aspartate residue.

Ключевые слова

Amyloid peptide Aβ13-23, NMR spectroscopy, Mn2+ ions

Название журнала

BioNanoScience

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https://repository.kpfu.ru/?p_id=148699

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Каратаева Фарида Хайдаровна	ru_RU
dc.contributor.author	Клочков Владимир Васильевич	ru_RU
dc.contributor.author	Усачев Константин Сергеевич	ru_RU
dc.contributor.author	Абдрахманов Рустам Жамилевич	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Binding of Mn2+ ions to the fragment of beta-amyloid peptide (Aβ13-23) was studied. Manganese complexation induces important structural changes within the C-terminal segment of the peptide. Investigation of peptide Ab metal ion binding was made by MnCl2 salt titration and recording 2D 1H-1H NMR TOCSY spectra (TOtal Correlation SpectroscopY). Multidimensional NMR techniques were performed to understand the details of the conformational behavior of the peptide and to reveal the metalbinding sites. According to changes in NMR spectra, the manganese-binding center of the Aβ13-23 peptide is associated with the aspartate residue.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=148699	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Amyloid peptide Aβ13-23	ru_RU
dc.subject	NMR spectroscopy	ru_RU
dc.subject	Mn2+ ions	ru_RU
dc.title	NMR Studies of the Mn2+ Interactions with Amyloid Peptide Aβ13-23 in Water Environment	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU