КФУ. Карточка публикации. NMR structure, conformational dynamics, and biological activity of PsDef1 defensin from Pinus sylvestris

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NMR STRUCTURE, CONFORMATIONAL DYNAMICS, AND BIOLOGICAL ACTIVITY OF PSDEF1 DEFENSIN FROM PINUS SYLVESTRIS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

английский

Авторы, сотрудники КФУ

Хайрутдинов Булат Имамутдинович, автор

Библиографическое описание на языке оригинала

Khairutdinov B.I, Ermakova E.A, Yusypovych Y.M, NMR structure, conformational dynamics, and biological activity of PsDef1 defensin from Pinus sylvestris//Biochimica et Biophysica Acta - Proteins and Proteomics. - 2017. - Vol.1865, Is.8. - P.1085-1094.

Аннотация

Plants have developed a complex defense response system against pests and pathogens. Defensins, produced by plants as part of their innate immune response, form the family of small, basic, cysteine-rich proteins with activity primarily directed against fungal pathogens. In addition, plant defensins can show antibacterial activity and protease and insect amylase inhibitory activities. However, in gymnosperms, only antifungal activity of defensins has been described thus far. Here, we report antibacterial and insect α-amylase inhibition activities for defensin PsDef1 from P. sylvestris, the first defensin from gymnosperms with a broad range of biological activities described. We also report the solution NMR structure of PsDef1 and its dynamics properties assessed by a combination of experimental NMR and computational techniques. Collectively, our data provide an insight into structure, dynamics, and functional properties of PsDef1 that could be common between defensins from this taxonomi

Ключевые слова

solution NMR, Scotts pine defensin, Plant defensin, NMR structure, Conformational dynamics, Antibacterial activity, Amylase inhibition

Название журнала

Biochimica et Biophysica Acta - Proteins and Proteomics

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020012286&doi=10.1016%2fj.bbapap.2017.05.012&partnerID=40&md5=1dd70d63bf94cbfd8200a5ee1b918ebf

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https://repository.kpfu.ru/?p_id=159815

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Хайрутдинов Булат Имамутдинович	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Khairutdinov B.I, Ermakova E.A, Yusypovych Y.M, NMR structure, conformational dynamics, and biological activity of PsDef1 defensin from Pinus sylvestris//Biochimica et Biophysica Acta - Proteins and Proteomics. - 2017. - Vol.1865, Is.8. - P.1085-1094.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=159815	ru_RU
dc.description.abstract	Biochimica et Biophysica Acta - Proteins and Proteomics	ru_RU
dc.description.abstract	Plants have developed a complex defense response system against pests and pathogens. Defensins, produced by plants as part of their innate immune response, form the family of small, basic, cysteine-rich proteins with activity primarily directed against fungal pathogens. In addition, plant defensins can show antibacterial activity and protease and insect amylase inhibitory activities. However, in gymnosperms, only antifungal activity of defensins has been described thus far. Here, we report antibacterial and insect α-amylase inhibition activities for defensin PsDef1 from P. sylvestris, the first defensin from gymnosperms with a broad range of biological activities described. We also report the solution NMR structure of PsDef1 and its dynamics properties assessed by a combination of experimental NMR and computational techniques. Collectively, our data provide an insight into structure, dynamics, and functional properties of PsDef1 that could be common between defensins from this taxonomi	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	solution NMR	ru_RU
dc.subject	Scotts pine defensin	ru_RU
dc.subject	Plant defensin	ru_RU
dc.subject	NMR structure	ru_RU
dc.subject	Conformational dynamics	ru_RU
dc.subject	Antibacterial activity	ru_RU
dc.subject	Amylase inhibition	ru_RU
dc.title	NMR structure, conformational dynamics, and biological activity of PsDef1 defensin from Pinus sylvestris	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU