КФУ. Карточка публикации. Unexpected activity of multiple targeted cancer drugs in regulating ciliary dynamics

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UNEXPECTED ACTIVITY OF MULTIPLE TARGETED CANCER DRUGS IN REGULATING CILIARY DYNAMICS

Форма представления

Тезисы и материалы конференций в зарубежных журналах и сборниках

Год публикации

2017

Авторы, сотрудники КФУ

Киселева Анна Алексеевна, автор

Авторы, аспиранты КФУ

Киселева Анна Алексеевна, автор

Библиографическое описание на языке оригинала

The primary cilium is an antenna-like structure protruding from the cell surface, which provides a platform for receptors for signaling systems including PDGF-alpha, Hedgehog, Wnt, and others that influence cell differentiation and proliferation decisions. Under normal physiological growth conditions, the cilium forms after mitosis and in quiescent cells, extending from a basal body centered at a centriole, with timed resorption in G0 or early G1. Cancer cells have altered ciliary dynamics, with some (medulloblastomas and basal cell carcinomas) often dependent on cilia, and other tumor types downregulating them. In prior work, we defıned Aurora-A, an oncogenic kinase typically thought of as a mitotic regulator, as transiently activated at the basal body, and absolutely required for resorption of cilia at the G0/G1 boundary, and we showed the targeted Aurora-A inhibitor entirely blocked ciliary resorption. In subsequent work, we found that a second drug, the EGFR inhibitor erlotinib, al

Ключевые слова

primary cilium, ALisertib, Sunitinib

Место издания

Washington DC

Издательство

AACR

URL

http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=105&DetailItemID=539&utm_source=social&utm_medium=twitter&utm_content=am17&utm_campaign=annual-meeting#.WU-7Amg19PY

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https://repository.kpfu.ru/?p_id=160420

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Киселева Анна Алексеевна	ru_RU
dc.contributor.author	Киселева Анна Алексеевна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	The primary cilium is an antenna-like structure protruding from the cell surface, which provides a platform for receptors for signaling systems including PDGF-alpha, Hedgehog, Wnt, and others that influence cell differentiation and proliferation decisions. Under normal physiological growth conditions, the cilium forms after mitosis and in quiescent cells, extending from a basal body centered at a centriole, with timed resorption in G0 or early G1. Cancer cells have altered ciliary dynamics, with some (medulloblastomas and basal cell carcinomas) often dependent on cilia, and other tumor types downregulating them. In prior work, we defıned Aurora-A, an oncogenic kinase typically thought of as a mitotic regulator, as transiently activated at the basal body, and absolutely required for resorption of cilia at the G0/G1 boundary, and we showed the targeted Aurora-A inhibitor entirely blocked ciliary resorption. In subsequent work, we found that a second drug, the EGFR inhibitor erlotinib, al	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=160420	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	AACR	ru_RU
dc.subject	primary cilium	ru_RU
dc.subject	ALisertib	ru_RU
dc.subject	Sunitinib	ru_RU
dc.title	Unexpected activity of multiple targeted cancer drugs in regulating ciliary dynamics	ru_RU
dc.type	Тезисы и материалы конференций в зарубежных журналах и сборниках	ru_RU