КФУ. Карточка публикации. Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential

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SALT STRESS INDUCED BIOSYNTHESIS OF BINASE II, THE SECOND BACILLUS PUMILUS 7P RIBONUCLEASE WITH THERAPEUTIC POTENTIAL

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Язык

русский

Авторы, сотрудники КФУ

Ильинская Ольга Николаевна, автор

Колпаков Алексей Иванович, автор

Харитонова Майя Александровна, автор

Библиографическое описание на языке оригинала

Kharitonova M.A. Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential /Кharitonova М.А. , А.I.Kolpakov., O.N. //BioNanoScience. -2017. -V.7, (1). –P. 148-150.

Аннотация

BioNanoSciens

Ключевые слова

Bacillus pumilus, biosynthesis activation, ribonuclease, binase II Salt stress

Название журнала

BioNanoSciens

URL

https://www.scopus.com/record/display.uri?eid=2-s2.0-85017658444&origin=resultslist&sort=plf-f&src=s&sid=48A7A765AA641A55C655397B6203AA62.wsnAw8kcdt7IPYLO0V48gA%3a20&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%287005874875%29&relpos=0&citeCnt=0&searchTerm=

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https://repository.kpfu.ru/?p_id=160777

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ильинская Ольга Николаевна	ru_RU
dc.contributor.author	Колпаков Алексей Иванович	ru_RU
dc.contributor.author	Харитонова Майя Александровна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Kharitonova M.A. Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential /Кharitonova М.А. , А.I.Kolpakov., O.N. //BioNanoScience. -2017. -V.7, (1). –P. 148-150.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=160777	ru_RU
dc.description.abstract	BioNanoSciens	ru_RU
dc.description.abstract	Besides the dominant well-studied low-molecular weight ribonuclease (RNase) binase I, Bacillus pumilus secretes a high-molecular weight binase II which differs from binase I by the absence of substrate specificity and the mode of RNA cleavage. Similar to many other RNases, binase II was proposed to have therapeutic potential. Deciphering molecular mechanisms of binase II biosynthesis regulation is required to boost expression of this RNase. Here, we have shown that increase of salinity in growth medium leads to elevated biosynthesis level of binase II. We detected in the binase II promoter the gene sequences homologous to the recognition sites of response regulator DegU. DegS-DegU signal transduction system is stimulated by high salt concentrations. Using the Bacillus subtilis strains with various mutations in DegU gene, we have shown that the DegS-DegU system is responsible for the increase of binase II gene expression under salt stress, indeed	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bacillus pumilus	ru_RU
dc.subject	biosynthesis activation	ru_RU
dc.subject	ribonuclease	ru_RU
dc.subject	binase II Salt stress	ru_RU
dc.title	Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU