| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2013 |
| Язык | английский |
|
Гнездилов Олег Иванович, автор
Филиппов Андрей Васильевич, автор
|
| Библиографическое описание на языке оригинала |
Munavirov B, Gnezdilov O, Rudakova M, Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass//Magnetic Resonance in Chemistry. - 2013. - Vol.51, Is.11. - P.750-755. |
| Аннотация |
Polyanion-coated lipid vesicles are proposed to have an appreciable potential for drug delivery because of their ability to control the permeability of lipid bilayers by environmental parameters such as pH and temperature. However, details of the interaction of this class of polymers with lipids and theirmechanisms of induced permeability are still being debated. In thiswork,we applied 1H NOESY to study details of the interaction of polyacrylic acid (PAA) fractions of molecular weights 5 and 240 kDa with
dimyristoylphosphatidylcholine vesicles.We showed that PAA of two differentmolecularmassesmodifies lipid bilayers increasing
disorder and probability of close contact between polar and hydrophobic groups. PAA molecules adsorb near the interface of lipid bilayers but do not penetrate into the hydrophobic core of the bilayer and, thus, cannot participate in formation of transbilayer channels, proposed in earlier works. |
| Ключевые слова |
Interaction, polyacrylic acid, lipid bilayers, polymer mass, NMR |
| Название журнала |
Magnetic Resonance in Chemistry
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885130275&partnerID=40&md5=848dd2bb59023b023c22ee5bc3cdf0d0 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=162912 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Гнездилов Олег Иванович |
ru_RU |
| dc.contributor.author |
Филиппов Андрей Васильевич |
ru_RU |
| dc.date.accessioned |
2013-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2013-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2013 |
ru_RU |
| dc.identifier.citation |
Munavirov B, Gnezdilov O, Rudakova M, Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass//Magnetic Resonance in Chemistry. - 2013. - Vol.51, Is.11. - P.750-755. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=162912 |
ru_RU |
| dc.description.abstract |
Magnetic Resonance in Chemistry |
ru_RU |
| dc.description.abstract |
Polyanion-coated lipid vesicles are proposed to have an appreciable potential for drug delivery because of their ability to control the permeability of lipid bilayers by environmental parameters such as pH and temperature. However, details of the interaction of this class of polymers with lipids and theirmechanisms of induced permeability are still being debated. In thiswork,we applied 1H NOESY to study details of the interaction of polyacrylic acid (PAA) fractions of molecular weights 5 and 240 kDa with
dimyristoylphosphatidylcholine vesicles.We showed that PAA of two differentmolecularmassesmodifies lipid bilayers increasing
disorder and probability of close contact between polar and hydrophobic groups. PAA molecules adsorb near the interface of lipid bilayers but do not penetrate into the hydrophobic core of the bilayer and, thus, cannot participate in formation of transbilayer channels, proposed in earlier works. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Interaction |
ru_RU |
| dc.subject |
polyacrylic acid |
ru_RU |
| dc.subject |
lipid bilayers |
ru_RU |
| dc.subject |
polymer mass |
ru_RU |
| dc.subject |
NMR |
ru_RU |
| dc.title |
Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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