Казанский (Приволжский) федеральный университет, КФУ
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UNCATALYZED CLICK REACTION BETWEEN PHENYL AZIDES AND ACROLEIN: 4-FORMYL-1,2,3-TRIAZOLINES AS “CLICKED” MARKERS FOR VISUALIZATIONS OF EXTRACELLULAR ACROLEIN RELEASED FROM OXIDATIVELY STRESSED CELLS
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2016
Языканглийский
  • Курбангалиева Альмира Рафаэловна, автор
  • Прадипта Абмара Рахмат, автор
  • Библиографическое описание на языке оригинала Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. - 2016. - V. 1. - № 5. - P. 623-632.
    Аннотация Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a ?click? manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.
    Ключевые слова acrolein, aryl azide, oxidative stress, cell imaging, click chemistry
    Название журнала ACS SENSORS
    URL http://pubs.acs.org/doi/abs/10.1021/acssensors.6b00122
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