| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2017 |
| Язык | английский |
|
Байдамшина Диана Рафисовна, автор
Богачев Михаил Игоревич, автор
Каюмов Айрат Рашитович, автор
Курбангалиева Альмира Рафаэловна, автор
Латыпова Лилия Зиннуровна, автор
Рожина Эльвира Вячеславовна, автор
Тризна Елена Юрьевна, автор
Фахруллин Равиль Фаридович, автор
Шарафутдинов Иршад Султанович, автор
|
|
Klinger-Strobel Mareike , автор
Makarewicz Oliwia , автор
Pletz Mathias W. , автор
|
| Библиографическое описание на языке оригинала |
Sharafutdinov I.S. Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus / I.S. Sharafutdinov, E.Y. Trizna, D.R. Baidamshina, M.N. Ryzhikova, R.R. Sibgatullina, A.M. Khabibrakhmanova, L.Z. Latypova, A.R. Kurbangalieva, E.V. Rozhina, M. Klinger-Strobel, R.F. Fakhrullin, M.W. Pletz, M.I. Bogachev, A.R. Kayumov, O. Makarewicz // Frontiers in microbiology. - 2017. - V.8. - P.2246. |
| Аннотация |
The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety. Minimal inhibitory and bactericidal concentration values (MIC and MBC) of F105 were 10 and 40 mg/L, respectively, suggesting F105 biocidal properties. F105 exhibits pronounced activity against biofilm-embedded S. aureus and increases the efficacy of aminoglycosides (amikacin, gentamicin, and kanamycin) and benzalkonium chloride with fractional inhibitory concentration index valu |
| Ключевые слова |
2(5H)-furanones, sulfones, Staphylococcus aureus, MRSA, biofilm, antimicrobials synergism |
| Название журнала |
Frontiers in Microbiology
|
| URL |
https://www.frontiersin.org/articles/10.3389/fmicb.2017.02246/full |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=174516 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Байдамшина Диана Рафисовна |
ru_RU |
| dc.contributor.author |
Богачев Михаил Игоревич |
ru_RU |
| dc.contributor.author |
Каюмов Айрат Рашитович |
ru_RU |
| dc.contributor.author |
Курбангалиева Альмира Рафаэловна |
ru_RU |
| dc.contributor.author |
Латыпова Лилия Зиннуровна |
ru_RU |
| dc.contributor.author |
Рожина Эльвира Вячеславовна |
ru_RU |
| dc.contributor.author |
Тризна Елена Юрьевна |
ru_RU |
| dc.contributor.author |
Фахруллин Равиль Фаридович |
ru_RU |
| dc.contributor.author |
Шарафутдинов Иршад Султанович |
ru_RU |
| dc.contributor.author |
Klinger-Strobel Mareike |
ru_RU |
| dc.contributor.author |
Makarewicz Oliwia |
ru_RU |
| dc.contributor.author |
Pletz Mathias W. |
ru_RU |
| dc.date.accessioned |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2017 |
ru_RU |
| dc.identifier.citation |
Sharafutdinov I.S. Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus / I.S. Sharafutdinov, E.Y. Trizna, D.R. Baidamshina, M.N. Ryzhikova, R.R. Sibgatullina, A.M. Khabibrakhmanova, L.Z. Latypova, A.R. Kurbangalieva, E.V. Rozhina, M. Klinger-Strobel, R.F. Fakhrullin, M.W. Pletz, M.I. Bogachev, A.R. Kayumov, O. Makarewicz // Frontiers in microbiology. - 2017. - V.8. - P.2246. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=174516 |
ru_RU |
| dc.description.abstract |
Frontiers in Microbiology |
ru_RU |
| dc.description.abstract |
The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety. Minimal inhibitory and bactericidal concentration values (MIC and MBC) of F105 were 10 and 40 mg/L, respectively, suggesting F105 biocidal properties. F105 exhibits pronounced activity against biofilm-embedded S. aureus and increases the efficacy of aminoglycosides (amikacin, gentamicin, and kanamycin) and benzalkonium chloride with fractional inhibitory concentration index valu |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
2(5H)-furanones |
ru_RU |
| dc.subject |
sulfones |
ru_RU |
| dc.subject |
Staphylococcus aureus |
ru_RU |
| dc.subject |
MRSA |
ru_RU |
| dc.subject |
biofilm |
ru_RU |
| dc.subject |
antimicrobials synergism |
ru_RU |
| dc.title |
Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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