КФУ. Карточка публикации. Modeling the Co2+ Binding to Amyloid Peptide Aβ13?23 in Water Environment by NMR Spectroscopy

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

MODELING THE CO2+ BINDING TO AMYLOID PEPTIDE Aβ13?23 IN WATER ENVIRONMENT BY NMR SPECTROSCOPY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Авторы, сотрудники КФУ

Блохин Дмитрий Сергеевич, автор

Клочков Владимир Васильевич, автор

Авторы, аспиранты КФУ

Абдрахманов Рустам Жамилевич, автор

Библиографическое описание на языке оригинала

Alzheimer's disease is a fatal neurodegenerative disorder involving the abnormal accumulation and deposition of peptides (amyloid-β, Aβ) derived from the amyloid precursor protein. Various factors that cause pathology data are revealed, but, at the moment, there is no clear understanding of the processes of plaque formation. This is interesting and actual problem because metals such as zinc, manganese, and others induce Aβ aggregation and fibril formation at high metal concentrations, while low concentration metal ions selectively destabilize the Aβ oligomeric species. In present paper, we report a structural studies of the Co2+ ion binding sites of Aβ fragments in water environment by 1D (1H) and 2D (1H-1H) NMR spectroscopy. According to the observed changes in the NMR spectra that were determined, the cobalt binding center of the Aβ13?23 peptide is associated with the aspartate and glutamine residues. Structural model of cobalt associated with Aβ peptide was obtained.

Ключевые слова

Amyloid peptideAβ13-23, NMR, model peptide, neurodegeneration, structure, alzheimer?s disease.

Название журнала

BioNanoScience

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=182742

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Блохин Дмитрий Сергеевич	ru_RU
dc.contributor.author	Клочков Владимир Васильевич	ru_RU
dc.contributor.author	Абдрахманов Рустам Жамилевич	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Alzheimer's disease is a fatal neurodegenerative disorder involving the abnormal accumulation and deposition of peptides (amyloid-β, Aβ) derived from the amyloid precursor protein. Various factors that cause pathology data are revealed, but, at the moment, there is no clear understanding of the processes of plaque formation. This is interesting and actual problem because metals such as zinc, manganese, and others induce Aβ aggregation and fibril formation at high metal concentrations, while low concentration metal ions selectively destabilize the Aβ oligomeric species. In present paper, we report a structural studies of the Co2+ ion binding sites of Aβ fragments in water environment by 1D (1H) and 2D (1H-1H) NMR spectroscopy. According to the observed changes in the NMR spectra that were determined, the cobalt binding center of the Aβ13?23 peptide is associated with the aspartate and glutamine residues. Structural model of cobalt associated with Aβ peptide was obtained.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=182742	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Amyloid peptideAβ13-23	ru_RU
dc.subject	NMR	ru_RU
dc.subject	model peptide	ru_RU
dc.subject	neurodegeneration	ru_RU
dc.subject	structure	ru_RU
dc.subject	alzheimer?s disease.	ru_RU
dc.title	Modeling the Co2+ Binding to Amyloid Peptide Aβ13?23 in Water Environment by NMR Spectroscopy	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU