КФУ. Карточка публикации. Interaction of different statins with model membranes by NMR data

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INTERACTION OF DIFFERENT STATINS WITH MODEL MEMBRANES BY NMR DATA

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2017

Авторы, сотрудники КФУ

Аганов Альберт Вартанович, автор

Аганова Оксана Вартановна, автор

Галиуллина Лейсан Фаритовна, автор

Клочков Владимир Васильевич, автор

Латфуллин Ильдус Анварович, автор

Авторы, аспиранты КФУ

Мусабирова Гузель Салаватовна, автор

Библиографическое описание на языке оригинала

L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. Interaction of different statins with model membranes by NMR data // BBA Biomembranes, V. 1859 I. 3, 2017.-P. 259-300.

Аннотация

Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins reduce the amount of lowdensity lipoprotein (LDL) cholesterol,which is known as awell-established risk factor for atherosclerosis. Despite the fact that statins have a common pharmacologic target essential to sterol biosynthesis, their efficacy, safety, and potential non-LDL actions vary significantly for different statins. There is a hypothesis that pharmacological features of statins depend on their location in cell membrane, but to the present day there is a lack of information in literature on interactions of statins with the surface of the cell membrane in liquid media. The results of NMR experiments showed that all studied statins form intermolecular complexes with models of cell membranes (dodecylphosphocholine micelles) in water solution. Locations of pravastatin, simvastatin, fluvastatin and cerivastatin on model membranes were established by NOESY NMR data.

Ключевые слова

NMR, Molecular complex, Dodecylphosphocholine, Micelles, Statins

Название журнала

Biochimica et Biophysica Acta - Biomembranes

URL

http://dx.doi.org/10.1016/j.bbamem.2016.12.006

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https://repository.kpfu.ru/?p_id=186717

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Аганов Альберт Вартанович	ru_RU
dc.contributor.author	Аганова Оксана Вартановна	ru_RU
dc.contributor.author	Галиуллина Лейсан Фаритовна	ru_RU
dc.contributor.author	Клочков Владимир Васильевич	ru_RU
dc.contributor.author	Латфуллин Ильдус Анварович	ru_RU
dc.contributor.author	Мусабирова Гузель Салаватовна	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. Interaction of different statins with model membranes by NMR data // BBA Biomembranes, V. 1859 I. 3, 2017.-P. 259-300.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=186717	ru_RU
dc.description.abstract	Biochimica et Biophysica Acta - Biomembranes	ru_RU
dc.description.abstract	Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins reduce the amount of lowdensity lipoprotein (LDL) cholesterol,which is known as awell-established risk factor for atherosclerosis. Despite the fact that statins have a common pharmacologic target essential to sterol biosynthesis, their efficacy, safety, and potential non-LDL actions vary significantly for different statins. There is a hypothesis that pharmacological features of statins depend on their location in cell membrane, but to the present day there is a lack of information in literature on interactions of statins with the surface of the cell membrane in liquid media. The results of NMR experiments showed that all studied statins form intermolecular complexes with models of cell membranes (dodecylphosphocholine micelles) in water solution. Locations of pravastatin, simvastatin, fluvastatin and cerivastatin on model membranes were established by NOESY NMR data.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NMR	ru_RU
dc.subject	Molecular complex	ru_RU
dc.subject	Dodecylphosphocholine	ru_RU
dc.subject	Micelles	ru_RU
dc.subject	Statins	ru_RU
dc.title	Interaction of different statins with model membranes by NMR data	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU