КФУ. Карточка публикации. Evaluation of skin irritation in rats using simultaneous laser Doppler flowmetry and oxygenation monitoring

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EVALUATION OF SKIN IRRITATION IN RATS USING SIMULTANEOUS LASER DOPPLER FLOWMETRY AND OXYGENATION MONITORING

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2016

Авторы, сотрудники КФУ

Абдуллин Тимур Илдарович, автор

Авторы, студенты КФУ

Данг Тхи Вьет Чинь , автор

Библиографическое описание на языке оригинала

The possibility of assessment of skin irritation in rats with the use of simultaneous laser Doppler flowmetry (LDF) and oxygenation monitoring was investigated. The study was designed according to ISO 10993-10 using formaldehyde as a model irritant. 4-Hour application of 1 % formaldehyde induced significant local increase in skin microcirculation for the first 2 days by a factor of up to 2.4, whereas tissue oxygenation increased in much lower extent. The microcirculation was significantly inhibited by 10 % formaldehyde following treatment and then it gradually increased for 24 and 48 h of recovery period. The results correlated with visual evaluation of skin edema and erythema in treated zones. LDF/oxygenation signals provide early information on skin irritation and damage in rat model. The technique is valuable for preclinical/toxicological studies of chemical substances and medical materials.

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https://repository.kpfu.ru/?p_id=188797

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Абдуллин Тимур Илдарович	ru_RU
dc.contributor.author	Данг Тхи Вьет Чинь	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	The possibility of assessment of skin irritation in rats with the use of simultaneous laser Doppler flowmetry (LDF) and oxygenation monitoring was investigated. The study was designed according to ISO 10993-10 using formaldehyde as a model irritant. 4-Hour application of 1 % formaldehyde induced significant local increase in skin microcirculation for the first 2 days by a factor of up to 2.4, whereas tissue oxygenation increased in much lower extent. The microcirculation was significantly inhibited by 10 % formaldehyde following treatment and then it gradually increased for 24 and 48 h of recovery period. The results correlated with visual evaluation of skin edema and erythema in treated zones. LDF/oxygenation signals provide early information on skin irritation and damage in rat model. The technique is valuable for preclinical/toxicological studies of chemical substances and medical materials.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=188797	ru_RU
dc.language.iso	ru	ru_RU
dc.title	Evaluation of skin irritation in rats using simultaneous laser Doppler flowmetry and oxygenation monitoring	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU