КФУ. Карточка публикации. In-vitro antitumor activity of new quaternary phosphonium salts, derivatives of 3-hydroxypyridine.

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IN-VITRO ANTITUMOR ACTIVITY OF NEW QUATERNARY PHOSPHONIUM SALTS, DERIVATIVES OF 3-HYDROXYPYRIDINE.

Форма представления

Зарубежные монографии

Год публикации

2018

Авторы, сотрудники КФУ

Ахунзянов Алмаз Анасович, автор

Габбасова Раиля Раушановна, автор

Иксанова Альфия Габдулахатовна, автор

Авторы, студенты КФУ

Куприянова Татьяна Викторовна, автор

Библиографическое описание на языке оригинала

This work presents the results of in-vitro biological activity studies of three novel anticancer agents, phosphonium salts based on the 3-hydroxypyridine scaffold, including one derivative of 4-deoxypyridoxine. Proliferation and viability of cells treated with these compounds was assessed by the colony formation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Effects of the compounds on apoptosis and cell cycle were studied by flow cytometry using annexin V-FITC/propidium iodide and propidium iodide staining, respectively. The influence of the compounds on mitochondrial membrane potential and intracellular reactive oxygen species was evaluated using tetramethyl rhodamine ethyl and DCFHA staining. Western blot analysis was used to study the changes in the expression of Bcl-xL, Bax, and caspase-3 apoptotic proteins. The treatment of ovarian adenocarcinoma cells OVCAR-4 with the tested compounds inhibited the growth and induced cell cycle arrest in the G1 phase. 3

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ахунзянов Алмаз Анасович	ru_RU
dc.contributor.author	Габбасова Раиля Раушановна	ru_RU
dc.contributor.author	Иксанова Альфия Габдулахатовна	ru_RU
dc.contributor.author	Куприянова Татьяна Викторовна	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	This work presents the results of in-vitro biological activity studies of three novel anticancer agents, phosphonium salts based on the 3-hydroxypyridine scaffold, including one derivative of 4-deoxypyridoxine. Proliferation and viability of cells treated with these compounds was assessed by the colony formation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Effects of the compounds on apoptosis and cell cycle were studied by flow cytometry using annexin V-FITC/propidium iodide and propidium iodide staining, respectively. The influence of the compounds on mitochondrial membrane potential and intracellular reactive oxygen species was evaluated using tetramethyl rhodamine ethyl and DCFHA staining. Western blot analysis was used to study the changes in the expression of Bcl-xL, Bax, and caspase-3 apoptotic proteins. The treatment of ovarian adenocarcinoma cells OVCAR-4 with the tested compounds inhibited the growth and induced cell cycle arrest in the G1 phase. 3	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=192257	ru_RU
dc.language.iso	ru	ru_RU
dc.title	In-vitro antitumor activity of new quaternary phosphonium salts, derivatives of 3-hydroxypyridine.	ru_RU
dc.type	Зарубежные монографии	ru_RU