| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | русский |
|
Польшаков Владимир Иванович, автор
|
|
Батуев Евгений Андреевич, автор
Манцызов Алексей Борисович, автор
|
| Библиографическое описание на языке оригинала |
Polshakov, V. I., Batuev, E. A., & Mantsyzov, A. B. (2019). NMR screening and studies of target–ligand interactions. Russian Chemical Reviews, 88(1), 59. |
| Аннотация |
Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs. |
| Ключевые слова |
NMR spectroscopy, protein-ligand interaction, NMR screening, biological targets, physiologically active compounds, rational drug design, fragment-based lead design, structure-activity relationship |
| Название журнала |
RUSSIAN CHEMICAL REVIEWS
|
| Ссылка для РПД |
http://dspace.kpfu.ru/xmlui/bitstream/handle/net/149808/2019_RusChemRev_1stpage_refs.pdf?sequence=1&isAllowed=y
|
| URL |
https://iopscience.iop.org/article/10.1070/RCR4836/meta |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=195615 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Польшаков Владимир Иванович |
ru_RU |
| dc.contributor.author |
Батуев Евгений Андреевич |
ru_RU |
| dc.contributor.author |
Манцызов Алексей Борисович |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Polshakov, V. I., Batuev, E. A., & Mantsyzov, A. B. (2019). NMR screening and studies of target–ligand interactions. Russian Chemical Reviews, 88(1), 59. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=195615 |
ru_RU |
| dc.description.abstract |
RUSSIAN CHEMICAL REVIEWS |
ru_RU |
| dc.description.abstract |
Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
NMR spectroscopy |
ru_RU |
| dc.subject |
protein-ligand interaction |
ru_RU |
| dc.subject |
NMR screening |
ru_RU |
| dc.subject |
biological targets |
ru_RU |
| dc.subject |
physiologically active compounds |
ru_RU |
| dc.subject |
rational drug design |
ru_RU |
| dc.subject |
fragment-based lead design |
ru_RU |
| dc.subject |
structure-activity relationship |
ru_RU |
| dc.title |
NMR screening and studies of target–ligand interactions |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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