КФУ. Карточка публикации. Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery

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TRANSPLANTATION OF MICROGLIA IN THE AREA OF SPINAL CORD INJURY IN AN ACUTE PERIOD INCREASES TISSUE SPARING, BUT NOT FUNCTIONAL RECOVERY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2018

Авторы, сотрудники КФУ

Ахметзянова Эльвира Руслановна, автор

Гаранина Екатерина Евгеньевна, автор

Журавлева Маргарита Николаевна, автор

Костенников Александр Александрович, автор

Мухамедшина Яна Олеговна, автор

Ризванов Альберт Анатольевич, автор

Другие авторы

Галиева Луиза Рамилевна

Авторы, аспиранты КФУ

Ахметзянова Эльвира Руслановна, автор

Библиографическое описание на языке оригинала

Akhmetzyanova, E. R., Mukhamedshina, Y. O., Zhuravleva, M. N., Galieva, L. R., Kostennikov, A. A., Garanina, E. E., & Rizvanov, A. A. (2018). Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery. Frontiers in cellular neuroscience, 12, 507. doi:10.3389/fncel.2018.00507

Аннотация

Microglial cells are known as important mediators of inflammation and immune response in the central nervous system (CNS). However, a neuroprotective role of these cells in post-traumatic processes should not be overlooked. Microglial cells are the first to respond to CNS injury and are further involved in all critical events of pathogenesis. When activated microglia clear the cellular debris and release anti- and proinflammatory cytokines and chemokines, nitric oxide, neurotrophins, and antioxidants capable of producing both neurotoxic and neuroprotective effects. The aim of this study was to determine to what extent the phagocytic activity of microglia in an acute period of spinal cord injury (SCI) in rats can effect the post-traumatic processes. For this purpose we implanted genetically modified Ad5-EGFP or Ad5-GDNF microglial cells into the area of acute SCI.

Ключевые слова

microglia, spinal cord injury, egfp, gdnf, adenoviral vector

Место издания

Лозанна

Название журнала

Frontiers in Cellular Neuroscience

Издательство

Frontiers

URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315181/

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https://repository.kpfu.ru/?p_id=203907

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ахметзянова Эльвира Руслановна	ru_RU
dc.contributor.author	Гаранина Екатерина Евгеньевна	ru_RU
dc.contributor.author	Журавлева Маргарита Николаевна	ru_RU
dc.contributor.author	Костенников Александр Александрович	ru_RU
dc.contributor.author	Мухамедшина Яна Олеговна	ru_RU
dc.contributor.author	Ризванов Альберт Анатольевич	ru_RU
dc.contributor.author	Ахметзянова Эльвира Руслановна	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Akhmetzyanova, E. R., Mukhamedshina, Y. O., Zhuravleva, M. N., Galieva, L. R., Kostennikov, A. A., Garanina, E. E., & Rizvanov, A. A. (2018). Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery. Frontiers in cellular neuroscience, 12, 507. doi:10.3389/fncel.2018.00507	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=203907	ru_RU
dc.description.abstract	Frontiers in Cellular Neuroscience	ru_RU
dc.description.abstract	Microglial cells are known as important mediators of inflammation and immune response in the central nervous system (CNS). However, a neuroprotective role of these cells in post-traumatic processes should not be overlooked. Microglial cells are the first to respond to CNS injury and are further involved in all critical events of pathogenesis. When activated microglia clear the cellular debris and release anti- and proinflammatory cytokines and chemokines, nitric oxide, neurotrophins, and antioxidants capable of producing both neurotoxic and neuroprotective effects. The aim of this study was to determine to what extent the phagocytic activity of microglia in an acute period of spinal cord injury (SCI) in rats can effect the post-traumatic processes. For this purpose we implanted genetically modified Ad5-EGFP or Ad5-GDNF microglial cells into the area of acute SCI.	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	Frontiers	ru_RU
dc.subject	microglia	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	egfp	ru_RU
dc.subject	gdnf	ru_RU
dc.subject	adenoviral vector	ru_RU
dc.title	Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU