| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2019 |
| Язык | русский |
|
Егорова Светлана Робертовна, автор
Ламберов Александр Адольфович, автор
|
| Библиографическое описание на языке оригинала |
Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties / A. R. Ibragimova, D. R. Gabdrakhmanov, A. R. Khamatgalimov, A. F. Saifina, A. T. Gubaidullin, S. R. Egorova, A. A. Lamberov, M. P. Danilaev, L. Ya. Zakharova //Russian Chemical Bulletin, International Edition. – 2019. - Vol. 68, No. 7. - pp. 1358—1365 |
| Аннотация |
MCM-41 type mesoporous silica particles were obtained using a template method in an
alkaline medium and cetyltrimethylammonium bromide as a matrix. The structural and adsorption
characteristics of the mesoporous material were studied by dynamic light scattering, scanning
electron microscopy, low-temperature adsorption—desorption of nitrogen, IR spectro scopy,
and simultaneous thermal analysis. It was shown that the obtained mesoporous material
possesses high porosity with the specifi c pore volume in excess of 1 cm3 g–1. It was established
that the size of silica particles does not exceed 200 nm, which is a value acceptable for the
penetration of drugs through cell membranes. The optimal compositions of aqueous dispersions
of MCM-41 with minimal sedimentation processes were determined. A drug (indomethacin)
was encapsulated into the silica pores using the precipitation method at various temperatures
(40 and 60 C), the quantitative parameters of loading effi ciency were calculated. The infl uence
of temperature on the encapsulation ability was demonstrated. |
| Ключевые слова |
template synthesis, MCM-41 type mesoporous silica, indomethacin, adsorption |
| Название журнала |
Russian Chemical Bulletin
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=212671 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Егорова Светлана Робертовна |
ru_RU |
| dc.contributor.author |
Ламберов Александр Адольфович |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties / A. R. Ibragimova, D. R. Gabdrakhmanov, A. R. Khamatgalimov, A. F. Saifina, A. T. Gubaidullin, S. R. Egorova, A. A. Lamberov, M. P. Danilaev, L. Ya. Zakharova //Russian Chemical Bulletin, International Edition. – 2019. - Vol. 68, No. 7. - pp. 1358—1365 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=212671 |
ru_RU |
| dc.description.abstract |
Russian Chemical Bulletin |
ru_RU |
| dc.description.abstract |
MCM-41 type mesoporous silica particles were obtained using a template method in an
alkaline medium and cetyltrimethylammonium bromide as a matrix. The structural and adsorption
characteristics of the mesoporous material were studied by dynamic light scattering, scanning
electron microscopy, low-temperature adsorption—desorption of nitrogen, IR spectro scopy,
and simultaneous thermal analysis. It was shown that the obtained mesoporous material
possesses high porosity with the specifi c pore volume in excess of 1 cm3 g–1. It was established
that the size of silica particles does not exceed 200 nm, which is a value acceptable for the
penetration of drugs through cell membranes. The optimal compositions of aqueous dispersions
of MCM-41 with minimal sedimentation processes were determined. A drug (indomethacin)
was encapsulated into the silica pores using the precipitation method at various temperatures
(40 and 60 C), the quantitative parameters of loading effi ciency were calculated. The infl uence
of temperature on the encapsulation ability was demonstrated. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
template synthesis |
ru_RU |
| dc.subject |
MCM-41 type mesoporous silica |
ru_RU |
| dc.subject |
indomethacin |
ru_RU |
| dc.subject |
adsorption |
ru_RU |
| dc.title |
Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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