КФУ. Карточка публикации. Detection of Macro-throtropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

DETECTION OF MACRO-THROTROPIN IN PATIENTS WITH HASHIMOTOS THYROIDITIS AND SUBCLINICAL HYPOTHYROIDISM

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2019

Язык

английский

Авторы, сотрудники КФУ

Абрамова Зинаида Ивановна, автор

Биктагирова Эльнара Маулетовна, автор

Невзорова Татьяна Александровна, автор

Авторы, аспиранты КФУ

Абрамов Сергей Николаевич, автор

Семаков Григорий Павлович, автор

Библиографическое описание на языке оригинала

Zolotoverkchova Z. I. Detection of Macro-thyrotropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism /Z. I. Zolotoverkchova, E. M. Biktagirova, G. P. Semakov, S.N. Abramov, T. A. Nevzorova, G. R. Vagapova, Z. I. Abramova //Human Gene Therapy.-2019.-V.30.- No. 11.-A120-120

Аннотация

The level of thyroid stimulating hormone (TSH) is one of the diagnostic markers of thyroid function. In subclinical hypothyroidism, the concentration of TSH in the blood serum increases, while the level of thyroid hormones stay the same. The reason for this observation is the macroTSH phenomenon, in which the macro isoforms of TSH (a complex of TSH with IgG) are present in the blood. Blood serum collected from 50 patients (30 patients with subclinical hypothyroidism, 10 - with manifest hypothyroidism, 10 - control group) was screened for the presence of macroTSH by polyethylene glycol (PEG)-precipitation and analyzed using gel filtration chromatography. As a result of the screening, 56–98% of 50–100% serum TSH was identified as true macroTSH. In patients with subclinical hypothyroidism with the TSH level of more than 10 μIU/ml, a trend towards an increase in the level of macroTSH has been shown. It is known that elevated levels of antibodies to thyroperoxidase (TPO) can lead to the generation of macroTSH. Thus, we identified that the amount of macroTSH complex in patients with subclinical hypothyroidism, in whom the level of antibodies to TPO is >500 U/L, is significantly higher compared with patients with manifest hypothyroidism. Patients with the TSH level of more than 10 μIU/ml are candidates for screening for the presence of the macroTSH complex. This research was supported by the subsidy of the Russian Government to support the Program of the competitive growth of Kazan Federal University.

Ключевые слова

thyroid stimulating hormone, Macro-thyrotropin, hashimotos thyroiditis

Название журнала

HUMAN GENE THERAPY

URL

https://www.liebertpub.com/doi/10.1089/hum.2019.29095.abstracts

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=214949

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Абрамова Зинаида Ивановна	ru_RU
dc.contributor.author	Биктагирова Эльнара Маулетовна	ru_RU
dc.contributor.author	Невзорова Татьяна Александровна	ru_RU
dc.contributor.author	Абрамов Сергей Николаевич	ru_RU
dc.contributor.author	Семаков Григорий Павлович	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Zolotoverkchova Z. I. Detection of Macro-thyrotropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism /Z. I. Zolotoverkchova, E. M. Biktagirova, G. P. Semakov, S.N. Abramov, T. A. Nevzorova, G. R. Vagapova, Z. I. Abramova //Human Gene Therapy.-2019.-V.30.- No. 11.-A120-120	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=214949	ru_RU
dc.description.abstract	HUMAN GENE THERAPY	ru_RU
dc.description.abstract	The level of thyroid stimulating hormone (TSH) is one of the diagnostic markers of thyroid function. In subclinical hypothyroidism, the concentration of TSH in the blood serum increases, while the level of thyroid hormones stay the same. The reason for this observation is the macroTSH phenomenon, in which the macro isoforms of TSH (a complex of TSH with IgG) are present in the blood. Blood serum collected from 50 patients (30 patients with subclinical hypothyroidism, 10 - with manifest hypothyroidism, 10 - control group) was screened for the presence of macroTSH by polyethylene glycol (PEG)-precipitation and analyzed using gel filtration chromatography. As a result of the screening, 56–98% of 50–100% serum TSH was identified as true macroTSH. In patients with subclinical hypothyroidism with the TSH level of more than 10 μIU/ml, a trend towards an increase in the level of macroTSH has been shown. It is known that elevated levels of antibodies to thyroperoxidase (TPO) can lead to the generation of macroTSH. Thus, we identified that the amount of macroTSH complex in patients with subclinical hypothyroidism, in whom the level of antibodies to TPO is >500 U/L, is significantly higher compared with patients with manifest hypothyroidism. Patients with the TSH level of more than 10 μIU/ml are candidates for screening for the presence of the macroTSH complex. This research was supported by the subsidy of the Russian Government to support the Program of the competitive growth of Kazan Federal University.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	thyroid stimulating hormone	ru_RU
dc.subject	Macro-thyrotropin	ru_RU
dc.subject	hashimotos thyroiditis	ru_RU
dc.title	Detection of Macro-throtropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU