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ANALYSIS OF AUTOPHAGY AND LC3-ASSOCIATED PHAGOCYTOSIS IN T-LYMPHOCYTES OF PATIENTS WITH SEVERE ASTHMA
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2019
Языканглийский
  • Абрамов Сергей Николаевич, автор
  • Абрамова Зинаида Ивановна, автор
  • Скибо Юлия Валерьевна, автор
  • Тихомирова Мария Владимировна, автор
  • Библиографическое описание на языке оригинала Abramov S. N. P352 Analysis of autophagy and LC3-associated phagocytosis in T-lymphocytes of patients with severe asthma/S. N. Abramov, Y. V. Skibo, A. Z. Abramova, M. V. Tihomirova //Human Gene Therapy,-2019.-V. 30, No. 11.-A120-A121
    Аннотация A lot of diseases are characterized by a dysfunction of apoptosis and immune activity, although one process is distinguished as a link between the appearance of autoantigens and impaired immune tolerance. Autophagy is a process of intracellular degradation, which is aimed at maintaining the cell homeostasis by delivering the cytoplasmic components to lysosomes. According to the studies, the greatest interest in the context of human diseases represents the non-canonical form of autophagy – LC3-associated phagocytosis (or LAP). For years, it has been assumed that asthma and autoimmune diseases have little in common, however, both of them are characterized by involving the immune system components, and in case of asthma, the autoimmune component. Thus, we performed a comprehensive ultrastructural analysis of apoptosis, autophagy and LAP in patients with severe bronchial asthma. By using the transmission electron microscopy, we found that the majority of T-lymphocytes in the control group have a morphology that is common for the early and late stages of apoptosis. Autophagosomes were not detected, however, a significant number of single-membrane phagosomes associated with the LAP pathway were found. In patients with severe asthma, in addition to the signs of the early stages of apoptosis, increased content of autophagosomes and a small number of single-membrane phagosomes were detected. As a result, a weak manifestation of LC3-associated phagocytosis, and the inhibition of apoptosis in the final stages may cause the appearance of autoantigens and the development of an autoimmune response. Study was funded by RFBR according to the research project №18-34-00739.
    Ключевые слова autophagy, LC3-associated phagocytosis, T-lymphocytes, asthma
    Название журнала HUMAN GENE THERAPY
    URL https://www.liebertpub.com/doi/10.1089/hum.2019.29095.abstracts
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