| Форма представления | Тезисы и материалы конференций в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | русский |
|
Абрамов Сергей Николаевич, автор
Абрамова Зинаида Ивановна, автор
Биктагирова Эльнара Маулетовна, автор
Невзорова Татьяна Александровна, автор
|
|
Семаков Григорий Павлович, автор
|
| Библиографическое описание на языке оригинала |
Zolotoverkchova Z. I. P351. Detection of Macro-thyrotropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism /Z. I Zolotoverkchovam E. M. Biktagirova, G. P. Semakov, S. N. Abramov, T. A. Nevzorova, G. R. Vagapova, Z. I. Abramova // ESGCT 27-th Annual Congress In collaboration with SETGyc Barcelona, Spain October 22-25, 2019.-A120. https://doi.org/10.1089/hum.2019.29095.abstracts |
| Аннотация |
ESGCT 27th Annual Congress In collaboration with SETGyc |
| Ключевые слова |
Macro-thyrotropin, Hashimotos Thyroiditis, subclinical hypothyroidism |
| Название журнала |
ESGCT 27th Annual Congress In collaboration with SETGyc
|
| URL |
https://doi.org/10.1089/hum.2019.29095.abstracts |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=215409 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абрамов Сергей Николаевич |
ru_RU |
| dc.contributor.author |
Абрамова Зинаида Ивановна |
ru_RU |
| dc.contributor.author |
Биктагирова Эльнара Маулетовна |
ru_RU |
| dc.contributor.author |
Невзорова Татьяна Александровна |
ru_RU |
| dc.contributor.author |
Семаков Григорий Павлович |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Zolotoverkchova Z. I. P351. Detection of Macro-thyrotropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism /Z. I Zolotoverkchovam E. M. Biktagirova, G. P. Semakov, S. N. Abramov, T. A. Nevzorova, G. R. Vagapova, Z. I. Abramova // ESGCT 27-th Annual Congress In collaboration with SETGyc Barcelona, Spain October 22-25, 2019.-A120. https://doi.org/10.1089/hum.2019.29095.abstracts |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=215409 |
ru_RU |
| dc.description.abstract |
ESGCT 27th Annual Congress In collaboration with SETGyc |
ru_RU |
| dc.description.abstract |
The level of thyroid stimulating hormone (TSH) is one of the
diagnostic markers of thyroid function. In subclinical hypothyroidism, the concentration of TSH in the blood serum increases,
while the level of thyroid hormones stay the same. The reason
for this observation is the macroTSH phenomenon, in which the
macro isoforms of TSH (a complex of TSH with IgG) are present
in the blood. Blood serum collected from 50 patients (30 patients
with subclinical hypothyroidism, 10 - with manifest hypothyroidism, 10 - control group) was screened for the presence of
macroTSH by polyethylene glycol (PEG)-precipitation and analyzed using gel filtration chromatography. As a result of the
screening, 56–98% of 50–100% serum TSH was identified as
true macroTSH. In patients with subclinical hypothyroidism
with the TSH level of more than 10 lIU/ml, a trend towards an
increase in the level of macroTSH has been shown. It is known
that elevated levels of antibodies to thyroperoxidase (TPO) can
lead to the generation of macroTSH. Thus, we identified that the
amount of macroTSH complex in patients with subclinical hypothyroidism, in whom the level of antibodies to TPO is >500 U/
L, is significantly higher compared with patients with manifest
hypothyroidism. Patients with the TSH level of more than
10 lIU/ml are candidates for screening for the presence of the
macroTSH complex. This research was supported by the subsidy
of the Russian Government to support the Program of the
competitive growth of Kazan Federal University |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Macro-thyrotropin |
ru_RU |
| dc.subject |
Hashimotos Thyroiditis |
ru_RU |
| dc.subject |
subclinical hypothyroidism |
ru_RU |
| dc.title |
Detection of Macro-throtropin in patients with Hashimotos Thyroiditis and subclinical hypothyroidism |
ru_RU |
| dc.type |
Тезисы и материалы конференций в зарубежных журналах и сборниках |
ru_RU |
|
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