| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | русский |
|
Богданов Андрей Владимирович, автор
Миронов Владимир Федорович, автор
|
| Библиографическое описание на языке оригинала |
A.V.Bogdanov, I.F.Zaripova, A.D.Voloshina, A.S.Sapunova, N.V.Kulik, S.V. Bukharov, J.K.Voronina, A.E.Vandyukov, V.F.Mironov. Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency. // Chemistry Select. 2019. Vol. 4. No 20. P. 6162-6166. Doi 10.1002/slct.201901708. |
| Аннотация |
A simple and easy condensation reaction of aryl- or Nsubstituted isatins with Girard's reagents P and T was found to be useful in obtaining of water-soluble isatin-based quaternary ammonium compounds (QACs) bearing pyridinium or trimethylammonium moiety with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 was shown. The influence of the substituent's nature as in the aromatic fragment as at position 1 on the activity was established. The most active are the pyridinium salts containing sterically hindered phenolic fragment at the position 1 of the heterocycle. The structures of all novel compounds were fully characterized using IR and NMR spectroscopies as well as XRD analysis. |
| Ключевые слова |
isatin, quaternary ammonium compounds, antimicrobial activity, XRD analysis |
| Название журнала |
CHEMISTRYSELECT
|
| URL |
https://onlinelibrary.wiley.com/doi/full/10.1002/slct.201901708 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=215420 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Богданов Андрей Владимирович |
ru_RU |
| dc.contributor.author |
Миронов Владимир Федорович |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
A.V.Bogdanov, I.F.Zaripova, A.D.Voloshina, A.S.Sapunova, N.V.Kulik, S.V. Bukharov, J.K.Voronina, A.E.Vandyukov, V.F.Mironov. Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency. // Chemistry Select. 2019. Vol. 4. No 20. P. 6162-6166. Doi 10.1002/slct.201901708. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=215420 |
ru_RU |
| dc.description.abstract |
CHEMISTRYSELECT |
ru_RU |
| dc.description.abstract |
A simple and easy condensation reaction of aryl- or Nsubstituted isatins with Girard's reagents P and T was found to be useful in obtaining of water-soluble isatin-based quaternary ammonium compounds (QACs) bearing pyridinium or trimethylammonium moiety with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 was shown. The influence of the substituent's nature as in the aromatic fragment as at position 1 on the activity was established. The most active are the pyridinium salts containing sterically hindered phenolic fragment at the position 1 of the heterocycle. The structures of all novel compounds were fully characterized using IR and NMR spectroscopies as well as XRD analysis. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
isatin |
ru_RU |
| dc.subject |
quaternary ammonium compounds |
ru_RU |
| dc.subject |
antimicrobial activity |
ru_RU |
| dc.subject |
XRD analysis |
ru_RU |
| dc.title |
Synthesis and biological evaluation of new isatin-based QACs with high antimicrobial potency. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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