КФУ. Карточка публикации. Antistaphylococcal activity of 2 (5H)-furanone derivatives

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ANTISTAPHYLOCOCCAL ACTIVITY OF 2 (5H)-FURANONE DERIVATIVES

Форма представления

Зарубежные монографии

Год публикации

2020

Язык

английский

Авторы, сотрудники КФУ

Богачев Михаил Игоревич, автор

Каюмов Айрат Рашитович, автор

Тризна Елена Юрьевна, автор

Шарафутдинов Иршад Султанович, автор

Библиографическое описание на языке оригинала

AR Kayumov, IS Sharafutdinov, EY Trizna, MI Bogachev. Antistaphylococcal activity of 2 (5H)-furanone derivatives / In: New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Biofilms: Current Research and Future Trends in Microbial Biofilms. Amsterdam: Elsevier, 2020. pp. 77-89.

Аннотация

The formation of the rigid biofilms by Staphylococcus aureus, the leading opportunistic pathogen causing a variety of nosocomial infections, strongly affects the healing of wounds because of the highly increased tolerance of biofilm-embedded bacteria to antimicrobials and elevated secretion of virulence factors. Therefore, the disintegration of biofilms on tissues and surfaces as well as suppression of the growth of the new ones or development of antimicrobials with ability to penetrate efficiently into the biofilm is a great challenge in infectious disease treatment. Among various low molecular weight compounds affecting the biofilm formation, the derivatives of 2(5H)-furanone have been intensively investigated as a potential antibiofilm agents. Most of them have been shown to interfere with autoinducer-1 (AI-1) and autoinducer-2 (AI-2) system of Gram-negative bacteria, a few compounds demonstrated antimicrobial and antibiofilm activities against Staphylococci as well. In this chapter an attempt has been made to describe the state-of-the-art knowledge about antimicrobial and biofilm-preventing activities of halogenated derivatives of 2(5H)-furanone. The mechanism of action and safety of compounds are also discussed.

Ключевые слова

Staphylococcus aureus,Biofilms,Extracellular matrix,Antibiotic resistance,Furanones

URL

https://www.sciencedirect.com/science/article/pii/B9780444642790000062

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https://repository.kpfu.ru/?p_id=220522

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Богачев Михаил Игоревич	ru_RU
dc.contributor.author	Каюмов Айрат Рашитович	ru_RU
dc.contributor.author	Тризна Елена Юрьевна	ru_RU
dc.contributor.author	Шарафутдинов Иршад Султанович	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	AR Kayumov, IS Sharafutdinov, EY Trizna, MI Bogachev. Antistaphylococcal activity of 2 (5H)-furanone derivatives / In: New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Biofilms: Current Research and Future Trends in Microbial Biofilms. Amsterdam: Elsevier, 2020. pp. 77-89.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=220522	ru_RU
dc.description.abstract	The formation of the rigid biofilms by Staphylococcus aureus, the leading opportunistic pathogen causing a variety of nosocomial infections, strongly affects the healing of wounds because of the highly increased tolerance of biofilm-embedded bacteria to antimicrobials and elevated secretion of virulence factors. Therefore, the disintegration of biofilms on tissues and surfaces as well as suppression of the growth of the new ones or development of antimicrobials with ability to penetrate efficiently into the biofilm is a great challenge in infectious disease treatment. Among various low molecular weight compounds affecting the biofilm formation, the derivatives of 2(5H)-furanone have been intensively investigated as a potential antibiofilm agents. Most of them have been shown to interfere with autoinducer-1 (AI-1) and autoinducer-2 (AI-2) system of Gram-negative bacteria, a few compounds demonstrated antimicrobial and antibiofilm activities against Staphylococci as well. In this chapter an attempt has been made to describe the state-of-the-art knowledge about antimicrobial and biofilm-preventing activities of halogenated derivatives of 2(5H)-furanone. The mechanism of action and safety of compounds are also discussed.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Staphylococcus aureus	ru_RU
dc.subject	Biofilms	ru_RU
dc.subject	Extracellular matrix	ru_RU
dc.subject	Antibiotic resistance	ru_RU
dc.subject	Furanones	ru_RU
dc.title	Antistaphylococcal activity of 2 (5H)-furanone derivatives	ru_RU
dc.type	Зарубежные монографии	ru_RU