| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | английский |
|
Бумбер Янис Алексеевич, автор
Денека Александр Ярославович, автор
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Beck Tim , автор
Chai Louis , автор
Golemis Erica , автор
Johal Priya , автор
Kanach Colin , автор
Laub Glenn , автор
|
| Библиографическое описание на языке оригинала |
Beck T.N. An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion / T.N. Beck, A.Y. Deneka, L. Chai, C. Kanach, P. Johal, N.J. Alvarez, Y. Boumber, E.A. Golemis, G.W. Laub // BMC Cancer. – 2019.-V.19, N.1.-A: 614. doi: 10.1186/s12885-019-5777-z. |
| Аннотация |
BMC Cancer |
| Ключевые слова |
Lung cancer, Metastatic cancer, Talc, Pleurodesis, Malignant pleural effusion, Mouse model, Sclerosing agent, Thermosensitive hydrogel |
| Название журнала |
BMC Cancer
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=220755 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Бумбер Янис Алексеевич |
ru_RU |
| dc.contributor.author |
Денека Александр Ярославович |
ru_RU |
| dc.contributor.author |
Beck Tim |
ru_RU |
| dc.contributor.author |
Chai Louis |
ru_RU |
| dc.contributor.author |
Golemis Erica |
ru_RU |
| dc.contributor.author |
Johal Priya |
ru_RU |
| dc.contributor.author |
Kanach Colin |
ru_RU |
| dc.contributor.author |
Laub Glenn |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Beck T.N. An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion / T.N. Beck, A.Y. Deneka, L. Chai, C. Kanach, P. Johal, N.J. Alvarez, Y. Boumber, E.A. Golemis, G.W. Laub // BMC Cancer. – 2019.-V.19, N.1.-A: 614. doi: 10.1186/s12885-019-5777-z. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=220755 |
ru_RU |
| dc.description.abstract |
BMC Cancer |
ru_RU |
| dc.description.abstract |
Background: Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a foam delivery system designed to more effectively coat the pleural cavity.
Methods: C57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) control, foam control (F), talc slurry (TS, 2 mg/g) or talc foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined.
Results: The TF group had significantly better survival than the TS group (21 vs 13.5 days, p < 0.0001). The average effusion volume was less in the talc groups compared to the control group (140 vs 628 μL, p < 0.001). TF induced significant lung fibrosis (p < 0.01), similar to TS. On CT, TF significantly (p < 0.05) reduced loss of right lung volume (by 30–40%) compared to the control group. This was not seen with TS (p > 0.05).
Conclusions: This report describes using a novel talc foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc foam from animal models into clinical trials. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Lung cancer |
ru_RU |
| dc.subject |
Metastatic cancer |
ru_RU |
| dc.subject |
Talc |
ru_RU |
| dc.subject |
Pleurodesis |
ru_RU |
| dc.subject |
Malignant pleural effusion |
ru_RU |
| dc.subject |
Mouse model |
ru_RU |
| dc.subject |
Sclerosing agent |
ru_RU |
| dc.subject |
Thermosensitive hydrogel |
ru_RU |
| dc.title |
An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
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