| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | английский |
|
Бумбер Янис Алексеевич, автор
Денека Александр Ярославович, автор
|
|
Beck Tim , автор
Golemis Erica , автор
|
| Библиографическое описание на языке оригинала |
Deneka A.Y. Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC)/ A.Y. Deneka, Y. Boumber, T. Beck, E.A. Golemis // Cancers.-2019. -V.11, Is.9. doi: 10.3390/cancers11091297 |
| Аннотация |
Cancers |
| Ключевые слова |
small cell lung cancer; antibody-drug conjugates; targeted therapy |
| Название журнала |
Cancers
|
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https://repository.kpfu.ru/?p_id=220757 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Бумбер Янис Алексеевич |
ru_RU |
| dc.contributor.author |
Денека Александр Ярославович |
ru_RU |
| dc.contributor.author |
Beck Tim |
ru_RU |
| dc.contributor.author |
Golemis Erica |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Deneka A.Y. Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC)/ A.Y. Deneka, Y. Boumber, T. Beck, E.A. Golemis // Cancers.-2019. -V.11, Is.9. doi: 10.3390/cancers11091297 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=220757 |
ru_RU |
| dc.description.abstract |
Cancers |
ru_RU |
| dc.description.abstract |
There are few effective therapies for small cell lung cancer (SCLC), a highly aggressive disease representing 15% of total lung cancers. With median survival <2 years, SCLC is one of the most lethal cancers. At present, chemotherapies and radiation therapy are commonly used for SCLC management. Few protein-targeted therapies have shown efficacy in improving overall survival; immune checkpoint inhibitors (ICIs) are promising agents, but many SCLC tumors do not express ICI targets such as PD-L1. This article presents an alternative approach to the treatment of SCLC: the use of drug conjugates, where a targeting moiety concentrates otherwise toxic agents in the vicinity of tumors, maximizing the differential between tumor killing and the cytotoxicity of normal tissues. Several tumor-targeted drug conjugate delivery systems exist and are currently being actively tested in the setting of SCLC. These include antibody-drug conjugates (ADCs), radioimmunoconjugates (RICs), small molecule-drug conjugates (SMDCs), and polymer-drug conjugates (PDCs). We summarize the basis of action for these targeting compounds, discussing principles of construction and providing examples of effective versus ineffective compounds, as established by preclinical and clinical testing. Such agents may offer new therapeutic options for the clinical management of this challenging disease in the future. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC) |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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