КФУ. Карточка публикации. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis.

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COMPONENTS OF THE RIBOSOME BIOGENESIS PATHWAY UNDERLIE ESTABLISHMENT OF TELOMERE LENGTH SET POINT IN ARABIDOPSIS.

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2020

Язык

английский

Авторы, сотрудники КФУ

Абдулкина Лилия Ринатовна, автор

Библиографическое описание на языке оригинала

Abdulkina, L.R., Kobayashi, C., Lovell, J.T. et al. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis. Nat Commun 10, 5479 (2019). https://doi.org/10.1038/s41467-019-13448-z

Аннотация

Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genes RPL5A and RPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation.

Ключевые слова

Natural variation in plants, telomeres

Название журнала

Nature Communications

URL

https://www.nature.com/articles/s41467-019-13448-z#data-availability

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https://repository.kpfu.ru/?p_id=224070

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Абдулкина Лилия Ринатовна	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Abdulkina, L.R., Kobayashi, C., Lovell, J.T. et al. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis. Nat Commun 10, 5479 (2019). https://doi.org/10.1038/s41467-019-13448-z	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=224070	ru_RU
dc.description.abstract	Nature Communications	ru_RU
dc.description.abstract	Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genes RPL5A and RPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Natural variation in plants	ru_RU
dc.subject	telomeres	ru_RU
dc.title	Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis.	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU