Казанский (Приволжский) федеральный университет, КФУ
КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ
 
STRUCTURAL DETAILS ON THE INTERACTION OF BIOLOGICALLY ACTIVE SULFUR-CONTAINING MONOTERPENOIDS WITH LIPID MEMBRANES
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2020
Языканглийский
  • Аганова Оксана Вартановна, автор
  • Галиуллина Лейсан Фаритовна, автор
  • Клочков Владимир Васильевич, автор
  • Никитина Лилия Евгеньевна, автор
  • Павельев Роман Сергеевич, автор
  • Старцева Валерия Андреевна, автор
  • Тимерова Айзира Флюсовна, автор
  • Ходов Илья Анатольевич, автор
  • Scheidt Holger A. , автор
  • Библиографическое описание на языке оригинала Nikitina L.E. Structural details on the interaction of biologically active sulfur-containing monoterpenoids with lipid membranes / L.E. Nikitina, R.S. Pavelyev, V.A. Startseva, S.V. Kiselev, L.F. Galiullina, O.V. Aganova, A.F. Timerova, S.V. Boichuk, Z.R. Azizova, V.V. Klochkov, D. Huster, I.A. Khodov, H.A. Scheidt, // J. Mol. Liq. – 2020. – V 301. – 112366.
    Аннотация In this work, we propose the synthesis of new thioterpenoids of a bornane series and study the influence of these compounds on hemostasis. The results from this study suggest that among all investigated terpenoids, sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetate may be the most promising for further development due to enhanced inhibition of the spontaneous aggregation compared with isoborneol, and because of its higher solubility in water compared with ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetic acid, which has approximately the same antiaggregatory and anticoagulant properties. In accordance with one hypothesis, the distribution of the studied bioactive molecules within the cellular lipid membrane can directly influence the anticoagulant properties. In the current work, the interactions of thioterpenoids with phospholipid membranes have been studied using various NMR techniques. The findings of this study indicate that sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetateexhibits a membrane location, which is shifted somewhat in the direction of the lipid-water interface. Such a location may shield the compound from interactions with hydrophobic lipid segments. In contrast, isoborneol is more deeply immersed in the membrane. These results represent an initial step toward developing new drugs based on the synthesized thioterpenoids in order to increase the effectiveness of treatment and prevention of several human diseases accompanying disorders in the hemostasis system.
    Ключевые слова Thioterpenoids, Isoborneol, Coagulation activity, Platelets aggregation, 1D and 2D solution-state NMR, Solid-state NMR, Model cell membranes, Molecular mechanism of coagulation activity, NOESY, DOSY
    Название журнала Journal of Molecular Liquids
    URL https://www.sciencedirect.com/science/article/pii/S016773221935994X?via%3Dihub
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