| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2019 |
| Язык | английский |
|
Сироткин Владимир Александрович, автор
|
| Библиографическое описание на языке оригинала |
Sirotkin, V.A. Preferential solvation of lysozyme in water-dimethyl sulfoxide mixtures: Gibbs energies of water and organic solvent. / In: Sirotkin V.A., (Ed.) Preferential solvation and hydration of proteins in water-organic mixtures: Two sides of one coin. - Nova Science Publishers, Inc., Hauppauge, NY, 2019. - P.91-122. |
| Аннотация |
Preferential solvation and hydration of proteins in water-organic mixtures: Two sides of one coin. |
| Ключевые слова |
Preferential solvation, lysozyme, water-dimethyl sulfoxide mixtures, Gibbs energies, water, organic solvent |
| Название журнала |
Preferential solvation and hydration of proteins in water-organic mixtures: Two sides of one coin.
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084275481&partnerID=40&md5=b603c8f11abb363f1985ace6d00f7ed2 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=233978 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Сироткин Владимир Александрович |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Sirotkin, V.A. Preferential solvation of lysozyme in water-dimethyl sulfoxide mixtures: Gibbs energies of water and organic solvent. / In: Sirotkin V.A., (Ed.) Preferential solvation and hydration of proteins in water-organic mixtures: Two sides of one coin. - Nova Science Publishers, Inc., Hauppauge, NY, 2019. - P.91-122. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=233978 |
ru_RU |
| dc.description.abstract |
Preferential solvation and hydration of proteins in water-organic mixtures: Two sides of one coin. |
ru_RU |
| dc.description.abstract |
Water/organic solvent sorption and residual enzyme activity were investigated to monitor preferential solvation and preferential hydration of protein macromolecules in the entire range of water content in organic liquids at 25?C. This approach was applied to estimate protein destabilization/stabilization due to the preferential interactions of hen-egg-white lysozyme with water-dimethyl sulfoxide (DMSO) mixtures. This approach facilitates the individual evaluation of the Gibbs energies of water, protein, and organic solvent. There are two concentration regimes. Lysozyme is preferentially hydrated at high water content. The residual enzyme activity values are close to 100%. At low water content, lysozyme has a higher affinity for DMSO than for water. The DMSO-induced irreversible inactivation of α-chymotrypsin was found in this region. Residual enzyme activity is close to zero in this concentration range. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Preferential solvation |
ru_RU |
| dc.subject |
lysozyme |
ru_RU |
| dc.subject |
water-dimethyl sulfoxide mixtures |
ru_RU |
| dc.subject |
Gibbs energies |
ru_RU |
| dc.subject |
water |
ru_RU |
| dc.subject |
organic solvent |
ru_RU |
| dc.title |
Preferential solvation of lysozyme in water-dimethyl sulfoxide mixtures: Gibbs energies of water and organic solvent. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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