Форма представления | Статьи в зарубежных журналах и сборниках |
Год публикации | 2020 |
Язык | английский |
|
Зиганшина Альбина Юлдузовна, автор
|
Библиографическое описание на языке оригинала |
Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161. |
Аннотация |
Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells. |
Ключевые слова |
резорцинарен, наноноситель |
Название журнала |
Supramolecular Chemistry
|
URL |
https://www.tandfonline.com/doi/full/10.1080/10610278.2020.1714620 |
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https://repository.kpfu.ru/?p_id=241110 |
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Поле DC |
Значение |
Язык |
dc.contributor.author |
Зиганшина Альбина Юлдузовна |
ru_RU |
dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2020 |
ru_RU |
dc.identifier.citation |
Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161. |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/?p_id=241110 |
ru_RU |
dc.description.abstract |
Supramolecular Chemistry |
ru_RU |
dc.description.abstract |
Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
резорцинарен |
ru_RU |
dc.subject |
наноноситель |
ru_RU |
dc.title |
Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene |
ru_RU |
dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|