КФУ. Карточка публикации. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

DOXORUBICIN DELIVERY BY POLYMER NANOCARRIER BASED ON N-METHYLGLUCAMINE RESORCINARENE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2020

Язык

английский

Авторы, сотрудники КФУ

Зиганшина Альбина Юлдузовна, автор

Библиографическое описание на языке оригинала

Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161.

Аннотация

Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells.

Ключевые слова

резорцинарен, наноноситель

Название журнала

Supramolecular Chemistry

URL

https://www.tandfonline.com/doi/full/10.1080/10610278.2020.1714620

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=241110

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зиганшина Альбина Юлдузовна	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Sergeeva T. Yu. Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene / T. Yu. Sergeeva, R. K. Mukhitova, L. R. Bakhtiozina, I. R. Nizameev, M. K. Kadirov, A. S. Sapunova, A. D. Voloshina, A. Y. Ziganshina, I. S. Antipin // Supramol. Chem. – 2020. – 32. – 150-161.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=241110	ru_RU
dc.description.abstract	Supramolecular Chemistry	ru_RU
dc.description.abstract	Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	резорцинарен	ru_RU
dc.subject	наноноситель	ru_RU
dc.title	Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU