Казанский (Приволжский) федеральный университет, КФУ
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ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ
 
DESIGN OF N-METHYL-D-GLUCAMINE-BASED RESORCIN[4]ARENE NANOPARTICLES FOR ENHANCED ASSEMBLY AND ENCAPSULATION ACTIVITIES EFFECTS / R. R. KASHAPOV, Y. S. RAZUVAYEVA
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2020
Языканглийский
  • Зиганшина Альбина Юлдузовна, автор
  • Библиографическое описание на языке оригинала Kashapov R. R. Design of N-Methyl-d-Glucamine-Based Resorcin[4]arene Nanoparticles for Enhanced assembly and encapsulation activities Effects / R. R. Kashapov, Y. S. Razuvayeva, A. Y. Ziganshina, R. K. Mukhitova, A. S. Sapunova, A. D. Voloshina, I. R. Nizameev, M. K. Kadirov, L. Ya. Zakharova // Mol. Pharmaceutics. – 2020. – 17. – 40-49.
    Аннотация The addition of specific chemical groups in a macrocycle structure influences its functional properties and, consequently, can provide new possibilities, among which are aggregation properties, water solubility, biocompatibility, stimuli response, biological activity, etc. Herein, we report synthesis of new resorcin[4]arene with N-methyl-d-glucamine groups on the upper rim and n-decyl chains on the lower rim, an investigation of its self-assembly behavior in aqueous media, and its use as a building block for the formation of drug nanocontainer. N-methyl-d-glucamine fragments in the resorcin[4]arene structure promote higher stability in solutions, simplification of self-aggregation, and increased biological activity. Antimicrobial and hemolytic activity assessment revealed that this resorcin[4]arene obtained is nontoxic. The study of cell penetration was carried out with both free and encapsulated doxorubicin (DOX). Surprisingly, DOX-loaded macrocycle aggregates are more efficient in causing apoptosis in human cancer cell line. Conceivably, this knowledge will help in the rational design of DOX combination for novel drug-administration strategies in cancer treatment.
    Ключевые слова resorcin[4]arene, nanocarrier, doxorubicin
    Название журнала Molecular Pharmaceutics
    URL https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00599
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