| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2018 |
| Язык | английский |
|
Ермакова Алина Марселовна, автор
Коновалов Александр Иванович, автор
Морозова Юлия Эрнестовна, автор
Шалаева Яна Викторовна, автор
|
|
Кадиров Марсил Кахирович, автор
Казакова Элла Хатибовна, автор
Низамеев Ирек Рашатович, автор
Сякаев Виктор Васильевич, автор
|
| Библиографическое описание на языке оригинала |
Shalaeva Ya.V., Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles. // Shalaeva Ya.V., Morozova Ju. E., Syakaev V. V., Ermakova A. M., Nizameev I. R., Kadirov M. K., Kazakova E. Kh., Konovalov A. I. // Supramol. Chem. – 2018. – V. 30. – P. 901-910. DOI: 10.1080/10610278.2018.1467015 |
| Аннотация |
Cooperative nanoscale associates of amido(dimethylamino) calixresorcinarenes with pentyl (C5) and undecyl (C11) substituents on lower rim with antitumor drug-methotrexate (MTX) in aqueous solution and on the surface of gold nanoparticles C5@Au and C11@Au were formed. The formation of nanoparticles was investigated by 1 H NMR, NMR FT-PGSE, 2D NOESY, DLS, TEM, spectrophotometry, fluorimetry. It was found that during the interaction of C5 or C11 macrocycles with MTX in aqueous solution, the latter generates dissociation of macrocycles self-associates with formation of cooperative macrocycle–MTX associates of smaller size due to multiple non-covalent interactions, which leads to increase in fluorescence intensity of MTX. In contrast, binding of
MTX by macrocyclic associates preorganized as bilayer on surface of gold nanoparticles through electrostatic interactions induces aggregation of C5@Au-MTX or C11@Au-MTX associates, which results in quenching of MTX fluorescence in solution. Such particles have possible potential in the field of binding and delivery of antitumor drugs. |
| Ключевые слова |
calixresorcinarene, supramolecular aggregates, gold nanoparticles,
methotrexate |
| Название журнала |
Supramolecular Chemistry
|
| URL |
https://www.tandfonline.com/doi/full/10.1080/10610278.2018.1467015 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=241484 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Ермакова Алина Марселовна |
ru_RU |
| dc.contributor.author |
Коновалов Александр Иванович |
ru_RU |
| dc.contributor.author |
Морозова Юлия Эрнестовна |
ru_RU |
| dc.contributor.author |
Шалаева Яна Викторовна |
ru_RU |
| dc.contributor.author |
Кадиров Марсил Кахирович |
ru_RU |
| dc.contributor.author |
Казакова Элла Хатибовна |
ru_RU |
| dc.contributor.author |
Низамеев Ирек Рашатович |
ru_RU |
| dc.contributor.author |
Сякаев Виктор Васильевич |
ru_RU |
| dc.date.accessioned |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2018-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2018 |
ru_RU |
| dc.identifier.citation |
Shalaeva Ya.V., Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles. // Shalaeva Ya.V., Morozova Ju. E., Syakaev V. V., Ermakova A. M., Nizameev I. R., Kadirov M. K., Kazakova E. Kh., Konovalov A. I. // Supramol. Chem. – 2018. – V. 30. – P. 901-910. DOI: 10.1080/10610278.2018.1467015 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=241484 |
ru_RU |
| dc.description.abstract |
Supramolecular Chemistry |
ru_RU |
| dc.description.abstract |
Cooperative nanoscale associates of amido(dimethylamino) calixresorcinarenes with pentyl (C5) and undecyl (C11) substituents on lower rim with antitumor drug-methotrexate (MTX) in aqueous solution and on the surface of gold nanoparticles C5@Au and C11@Au were formed. The formation of nanoparticles was investigated by 1 H NMR, NMR FT-PGSE, 2D NOESY, DLS, TEM, spectrophotometry, fluorimetry. It was found that during the interaction of C5 or C11 macrocycles with MTX in aqueous solution, the latter generates dissociation of macrocycles self-associates with formation of cooperative macrocycle–MTX associates of smaller size due to multiple non-covalent interactions, which leads to increase in fluorescence intensity of MTX. In contrast, binding of
MTX by macrocyclic associates preorganized as bilayer on surface of gold nanoparticles through electrostatic interactions induces aggregation of C5@Au-MTX or C11@Au-MTX associates, which results in quenching of MTX fluorescence in solution. Such particles have possible potential in the field of binding and delivery of antitumor drugs. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
calixresorcinarene |
ru_RU |
| dc.subject |
supramolecular aggregates |
ru_RU |
| dc.subject |
gold nanoparticles |
ru_RU |
| dc.subject |
methotrexate |
ru_RU |
| dc.title |
Formation of cooperative amidoaminocalixresorcinarene – methotrexate nanosized aggregates in an aqueous solution and on the surface of gold nanoparticles |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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