КФУ. Карточка публикации. Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association.

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SOLUBILIZATION OF AZO-DYE-MODIFIED ISATIN DERIVATIVE BY AMPHIPHILIC CARBOXYRESORCINARENES: THE EFFECT OF MACROCYCLE STRUCTURE ON THE SUPRAMOLECULAR ASSOCIATION.

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2018

Язык

английский

Авторы, сотрудники КФУ

Богданов Андрей Владимирович, автор

Ермакова Алина Марселовна, автор

Коновалов Александр Иванович, автор

Миронов Владимир Федорович, автор

Морозова Юлия Эрнестовна, автор

Шалаева Яна Викторовна, автор

Другие авторы

Волошина Александра Дмитриевна, автор

Зобов Владимир Васильевич, автор

Кадиров Марсил Кахирович, автор

Низамеев Ирек Рашатович, автор

Сякаев Виктор Васильевич, автор

Библиографическое описание на языке оригинала

Syakaev V. V., Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association. / Syakaev V. V., Morozova Ju. E., Bogdanov A. V., Shalaeva Ya. V., Ermakova A. M., Voloshina A. D., Zobov V. V., Nizameev I. R., Kadirov M. K., Mironov V. F., Konovalov A. I. // Colloids Surf., A. – 2018. – V. 553. – P. 368-377. DOI: 10.1016/j.colsurfa.2018.05.078

Аннотация

Here we present the consecutive study of colloid systems formed by novel isatin derivative as compound with high pharmacological potential and series of carboxyresorcinarenes. The azo-modiﬁed isatin derivative bearing ammonium moiety (I-3) was synthesized and its antimicrobial activity was investigated. To increase its solubility the solubilization experiment using amphiphilic carboxyresorcinarenes, characterized by low hemolytic activity, was carried out. The I-3 – macrocycles systems were studied by NMR, UV–vis, DLS and TEM. The FT PGSE and 2D NOESY NMR methods demonstrated, that solubilization of I-3 is caused by the incorporation of its molecules in the hydrophobic part of the macrocycles associates. Herewith the loading eﬃciency of I-3 into the macro- cycles associates was reached of 20–30% due to the change of the volume of hydrophobic part of associates by varying the length and structure of hydrophobic substituents of macrocyclic amphiphiles

Ключевые слова

Isatin derivative, NMR spectroscopy, Resorcinarene, Solubilization, Supramolecular systems

Название журнала

Colloids and Surfaces A: Physicochemical and Engineering Aspects

URL

https://www.sciencedirect.com/science/article/pii/S0927775718304540?via%3Dihub

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https://repository.kpfu.ru/?p_id=241485

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Богданов Андрей Владимирович	ru_RU
dc.contributor.author	Ермакова Алина Марселовна	ru_RU
dc.contributor.author	Коновалов Александр Иванович	ru_RU
dc.contributor.author	Миронов Владимир Федорович	ru_RU
dc.contributor.author	Морозова Юлия Эрнестовна	ru_RU
dc.contributor.author	Шалаева Яна Викторовна	ru_RU
dc.contributor.author	Волошина Александра Дмитриевна	ru_RU
dc.contributor.author	Зобов Владимир Васильевич	ru_RU
dc.contributor.author	Кадиров Марсил Кахирович	ru_RU
dc.contributor.author	Низамеев Ирек Рашатович	ru_RU
dc.contributor.author	Сякаев Виктор Васильевич	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Syakaev V. V., Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association. / Syakaev V. V., Morozova Ju. E., Bogdanov A. V., Shalaeva Ya. V., Ermakova A. M., Voloshina A. D., Zobov V. V., Nizameev I. R., Kadirov M. K., Mironov V. F., Konovalov A. I. // Colloids Surf., A. – 2018. – V. 553. – P. 368-377. DOI: 10.1016/j.colsurfa.2018.05.078	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=241485	ru_RU
dc.description.abstract	Colloids and Surfaces A: Physicochemical and Engineering Aspects	ru_RU
dc.description.abstract	Here we present the consecutive study of colloid systems formed by novel isatin derivative as compound with high pharmacological potential and series of carboxyresorcinarenes. The azo-modiﬁed isatin derivative bearing ammonium moiety (I-3) was synthesized and its antimicrobial activity was investigated. To increase its solubility the solubilization experiment using amphiphilic carboxyresorcinarenes, characterized by low hemolytic activity, was carried out. The I-3 – macrocycles systems were studied by NMR, UV–vis, DLS and TEM. The FT PGSE and 2D NOESY NMR methods demonstrated, that solubilization of I-3 is caused by the incorporation of its molecules in the hydrophobic part of the macrocycles associates. Herewith the loading eﬃciency of I-3 into the macro- cycles associates was reached of 20–30% due to the change of the volume of hydrophobic part of associates by varying the length and structure of hydrophobic substituents of macrocyclic amphiphiles	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Isatin derivative	ru_RU
dc.subject	NMR spectroscopy	ru_RU
dc.subject	Resorcinarene	ru_RU
dc.subject	Solubilization	ru_RU
dc.subject	Supramolecular systems	ru_RU
dc.title	Solubilization of azo-dye-modified isatin derivative by amphiphilic carboxyresorcinarenes: the effect of macrocycle structure on the supramolecular association.	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU