| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2020 |
| Язык | английский |
|
Хайруллин Рафиль Фидаилевич, автор
|
|
Макарова Алена Владимировна, автор
|
| Библиографическое описание на языке оригинала |
Shilkin E., Boldinova E., Stolyarenko A., Goncharova RI., Chuprov-Netochin RN.,
Khairullin RF, Smal MP, Makarova AV Translesion DNA Synthesis and Carcinogenesis. Biochemistry Moscow 85, 425–435 (2020). |
| Аннотация |
Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer. |
| Ключевые слова |
DNA Synthesis, Carcinogenesis, polymerases, mutation |
| Название журнала |
Biochemistry (Moscow)
|
| URL |
https://link.springer.com/article/10.1134/S0006297920040033#citeas |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=242007 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Хайруллин Рафиль Фидаилевич |
ru_RU |
| dc.contributor.author |
Макарова Алена Владимировна |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Shilkin E., Boldinova E., Stolyarenko A., Goncharova RI., Chuprov-Netochin RN.,
Khairullin RF, Smal MP, Makarova AV Translesion DNA Synthesis and Carcinogenesis. Biochemistry Moscow 85, 425–435 (2020). |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=242007 |
ru_RU |
| dc.description.abstract |
Biochemistry (Moscow) |
ru_RU |
| dc.description.abstract |
Tens of thousands of DNA lesions are formed in mammalian cells each day. DNA translesion synthesis is the main mechanism of cell defense against unrepaired DNA lesions. DNA polymerases iota (Pol ι), eta (Pol η), kappa (Pol κ), and zeta (Pol ζ) have active sites that are less stringent toward the DNA template structure and efficiently incorporate nucleotides opposite DNA lesions. However, these polymerases display low accuracy of DNA synthesis and can introduce mutations in genomic DNA. Impaired functioning of these enzymes can lead to an increased risk of cancer. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
DNA Synthesis |
ru_RU |
| dc.subject |
Carcinogenesis |
ru_RU |
| dc.subject |
polymerases |
ru_RU |
| dc.subject |
mutation |
ru_RU |
| dc.title |
Translesion DNA Synthesis and Carcinogenesis |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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