КФУ. Карточка публикации. Interaction of Lovastatin with Model Membranes by NMR Data and from MD Simulations

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INTERACTION OF LOVASTATIN WITH MODEL MEMBRANES BY NMR DATA AND FROM MD SIMULATIONS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2020

Язык

английский

Авторы, сотрудники КФУ

Клочков Владимир Васильевич, автор

Мусабирова Гузель Салаватовна, автор

Юльметов Айдар Рафаилевич, автор

Авторы, аспиранты КФУ

Мусабирова Гузель Салаватовна, автор

Авторы, студенты КФУ

Шарапова Диана Айдаровна, автор

Библиографическое описание на языке оригинала

Shurshalova G.S. Interaction of Lovastatin with Model Membranes by NMR Data and from MD Simulations / Shurshalova, G.S., Yulmetov, A.R., Sharapova, D.A., Aganov, A.V., Klochkov, V.V. // BioNanoScience, 2020, 10(2), стр. 493-501

Аннотация

Lovastatin is a drug of the statin group which possesses the ability to decrease low-density lipoprotein cholesterol level by the competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. There is a hypothesis that pharmacological features of statins depend on their location in cell membrane, but to the present day, there is a lack of information in literature on interactions of statins with the surface of the cell membrane in liquid media. Intermolecular complex of lovastatin with dodecylphosphocholine (DPC) and sodium dodecylsulfate (SDS) micelles was investigated by NMR and computational methods. The results of NMR experiments and molecular dynamics (MD) simulation data showed that lovastatin forms intermolecular complexes with models of cell membranes in water solution. Locations of lovastatin on model membranes were established by NOESY NMR data. Distinctions in their positions can explain differences in pharmacological properties of studied compound. ? 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Ключевые слова

Lovastatin, Micelles, Molecular complex, Molecular dynamics, Nuclear magnetic resonance, Nuclear Overhauser effect

Название журнала

BioNanoScience

URL

https://link.springer.com/article/10.1007/s12668-020-00722-4

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https://repository.kpfu.ru/?p_id=242291

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Клочков Владимир Васильевич	ru_RU
dc.contributor.author	Мусабирова Гузель Салаватовна	ru_RU
dc.contributor.author	Юльметов Айдар Рафаилевич	ru_RU
dc.contributor.author	Шарапова Диана Айдаровна	ru_RU
dc.contributor.author	Мусабирова Гузель Салаватовна	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Shurshalova G.S. Interaction of Lovastatin with Model Membranes by NMR Data and from MD Simulations / Shurshalova, G.S., Yulmetov, A.R., Sharapova, D.A., Aganov, A.V., Klochkov, V.V. // BioNanoScience, 2020, 10(2), стр. 493-501	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=242291	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Lovastatin is a drug of the statin group which possesses the ability to decrease low-density lipoprotein cholesterol level by the competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. There is a hypothesis that pharmacological features of statins depend on their location in cell membrane, but to the present day, there is a lack of information in literature on interactions of statins with the surface of the cell membrane in liquid media. Intermolecular complex of lovastatin with dodecylphosphocholine (DPC) and sodium dodecylsulfate (SDS) micelles was investigated by NMR and computational methods. The results of NMR experiments and molecular dynamics (MD) simulation data showed that lovastatin forms intermolecular complexes with models of cell membranes in water solution. Locations of lovastatin on model membranes were established by NOESY NMR data. Distinctions in their positions can explain differences in pharmacological properties of studied compound. ? 2020, Springer Science+Business Media, LLC, part of Springer Nature.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Lovastatin	ru_RU
dc.subject	Micelles	ru_RU
dc.subject	Molecular complex	ru_RU
dc.subject	Molecular dynamics	ru_RU
dc.subject	Nuclear magnetic resonance	ru_RU
dc.subject	Nuclear Overhauser effect	ru_RU
dc.title	Interaction of Lovastatin with Model Membranes by NMR Data and from MD Simulations	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU