КФУ. Карточка публикации. Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats

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HYPERHOMOCYSTEINEMIA INCREASES SUSCEPTIBILITY TO CORTICAL SPREADING DEPRESSION ASSOCIATED WITH PHOTOPHOBIA, MECHANICAL ALLODYNIA, AND ANXIETY IN RATS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Язык

русский

Авторы, сотрудники КФУ

Герасимова Елена Вячеславовна, автор

Библиографическое описание на языке оригинала

ElenaGerasimova,Gulshat Burkhanova,Kseniya Chernova, AndreyZakharov,,Daniel Enikeev, Nail Khaertdinov, Rashid Giniatullin,Guzel Sitdikova// Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats// Behavioural Brain Research.-2021.- V. 409,.-р.1-8 https://doi.org/10.1016/j.bbr.2021.113324.

Аннотация

Behavioural Brain Research

Ключевые слова

Migraine, Hyperhomocysteinemia,Cortical spreading depression Cortical excitability,Allodynia,Anxiety

Название журнала

Behavioural Brain Research

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https://repository.kpfu.ru/?p_id=252550

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Герасимова Елена Вячеславовна	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	ElenaGerasimova,Gulshat Burkhanova,Kseniya Chernova, AndreyZakharov,,Daniel Enikeev, Nail Khaertdinov, Rashid Giniatullin,Guzel Sitdikova// Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats// Behavioural Brain Research.-2021.- V. 409,.-р.1-8 https://doi.org/10.1016/j.bbr.2021.113324.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=252550	ru_RU
dc.description.abstract	Behavioural Brain Research	ru_RU
dc.description.abstract	Epidemiological data suggest that elevated homocysteine is associated with migraine with aura. However, how homocysteine contributes to migraine is still unclear. Here, we tested whether hyperhomocysteinemia (hHCY) promotes cortical spreading depression (CSD), a phenomenon underlying migraine with aura, and whether hHCY contributes to pain behavior. hHCY was induced by dietary methionine in female rats while the testing was performed on their 6–8week-old offspring. CSD and multiple unit activity (MUA) induced by KCl were recorded from the primary somatosensory cortex, S1, using multichannel electrodes. In hHCY rats, compared to control, we found: i) higher probability of CSD occurrence; ii) induction of CSD by lower concentrations of KCl; iii) faster horizontal propagation of CSD; iv) smaller CSD with longer duration; v) higher frequency of MUA at CSD onset along with slower reappearance. Rats with hHCY demonstrated high level of locomotor activity and grooming while spent less time in the central area of the open field, indicating anxiety. These animals showed light sensitivity and facial mechanical allodinia. Thus, hHCY acquired at birth promotes multiple features of migraine such as higher cortical excitability, mechanical allodynia, photophobia, and anxiety. Our results provide the first experimental explanation for the higher occurrence of migraine with aura in patients with hHCY.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Migraine	ru_RU
dc.subject	Hyperhomocysteinemia	ru_RU
dc.subject	Cortical spreading depression Cortical excitability	ru_RU
dc.subject	Allodynia	ru_RU
dc.subject	Anxiety	ru_RU
dc.title	Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU