| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2021 |
| Язык | русский |
|
Абрамова Зинаида Ивановна, автор
|
|
Афанасьева Зинаида Александровна, автор
Гарипов Карим Альбертович, автор
Гафиуллина Алия Дамировна, автор
|
| Библиографическое описание на языке оригинала |
Гафиуллина А. Д. Влияние некоторых белков аутофагии (LC3b и Beclin1) и апоптоза (Casp8 и Bcl2) на клиническое течение рака яичников /А. Д. Гафиуллина, З. А. Афанасьева, К. А. Гарипов, З. И. Абрамова //Вопросы онкологии.- 2021.- Т. 67, №4.- С.474-479 (Q4) https://elibrary.ru/item.asp?id=46503550& |
| Аннотация |
Treatment of ovarian cancer remains an important problem
in practical oncology due to the increase in morbidity and
mortality from this disease.
The aim is to summarize the available literature data on the
molecular mechanisms of the participation of various proteins
of autophagy and apoptosis in the development, progression,
formation of chemoresistance and in the assessment of the
prognosis of epithelial ovarian cancer.
Materials and methods. The search for information was
carried out in the materials of the databases Medline, Cochrane
Library, Elibrary, NCBI, RSCI, instructions for the medical use
of drugs, using keywords in the title. Used 39 articles to write
this systematic review.
Results. The review examines the molecular mechanisms of
autophagy and apoptosis involved in the progression of ovarian
cancer and in the formation of resistance to anticancer drug
therapy. It has been shown that modulation of autophagy and
apoptosis can change the effectiveness of drug treatment for
this tumor.
Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian
cancer and the formation of resistance to antitumor treatment,
further study is required and the search for new molecular
targets for their modulation is required. |
| Ключевые слова |
обзор, эпителиальный рак яичников, аутофагия, апоптоз, препараты платины, химиорезистентность ХИМИОРЕЗИСТЕНТНОСТЬ |
| Название журнала |
Вопросы онкологии
|
| URL |
https://doi.org/10.37469/0507-3758-2021-67-4-474-479 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=253312 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абрамова Зинаида Ивановна |
ru_RU |
| dc.contributor.author |
Афанасьева Зинаида Александровна |
ru_RU |
| dc.contributor.author |
Гарипов Карим Альбертович |
ru_RU |
| dc.contributor.author |
Гафиуллина Алия Дамировна |
ru_RU |
| dc.date.accessioned |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2021 |
ru_RU |
| dc.identifier.citation |
Гафиуллина А. Д. Влияние некоторых белков аутофагии (LC3b и Beclin1) и апоптоза (Casp8 и Bcl2) на клиническое течение рака яичников /А. Д. Гафиуллина, З. А. Афанасьева, К. А. Гарипов, З. И. Абрамова //Вопросы онкологии.- 2021.- Т. 67, №4.- С.474-479 (Q4) https://elibrary.ru/item.asp?id=46503550& |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=253312 |
ru_RU |
| dc.description.abstract |
Вопросы онкологии |
ru_RU |
| dc.description.abstract |
Treatment of ovarian cancer remains an important problem
in practical oncology due to the increase in morbidity and
mortality from this disease.
The aim is to summarize the available literature data on the
molecular mechanisms of the participation of various proteins
of autophagy and apoptosis in the development, progression,
formation of chemoresistance and in the assessment of the
prognosis of epithelial ovarian cancer.
Materials and methods. The search for information was
carried out in the materials of the databases Medline, Cochrane
Library, Elibrary, NCBI, RSCI, instructions for the medical use
of drugs, using keywords in the title. Used 39 articles to write
this systematic review.
Results. The review examines the molecular mechanisms of
autophagy and apoptosis involved in the progression of ovarian
cancer and in the formation of resistance to anticancer drug
therapy. It has been shown that modulation of autophagy and
apoptosis can change the effectiveness of drug treatment for
this tumor.
Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian
cancer and the formation of resistance to antitumor treatment,
further study is required and the search for new molecular
targets for their modulation is required. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
обзор |
ru_RU |
| dc.subject |
эпителиальный рак яичников |
ru_RU |
| dc.subject |
аутофагия |
ru_RU |
| dc.subject |
апоптоз |
ru_RU |
| dc.subject |
препараты платины |
ru_RU |
| dc.subject |
химиорезистентность ХИМИОРЕЗИСТЕНТНОСТЬ |
ru_RU |
| dc.title |
Влияние некоторых белков аутофагии (LC3b и Beclin1) и апоптоза (Casp8 и Bcl2) на клиническое течение рака яичников |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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