| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2021 |
| Язык | русский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Купцова Анна Михайловна, автор
Хабибрахманов Инсаф Илхамович, автор
|
|
Бугров Роман Кутдусович, автор
Кобзарев Роман Сергеевич, автор
|
| Библиографическое описание на языке оригинала |
Kuptsova A.M. Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction / A.M. Kuptsova, R.K. Bugrov, I.I. Khabibrakhmanov, R.S. Kobzarev, N.I. Ziyatdinova, T.L. Zefirov // Journal of Chemical Health Risks. 2021. - Vol. 11(2). pp. 129-134 |
| Аннотация |
Chronic adrenergic and angiotensin-energic stimulation of the heart muscle is one of the main causes of the onset and development of heart failure. α2-AR is widespread in the cardiovascular system and can be further applied and introduced into the heart's regenerative cell therapy. This study's objective was to study the effect of α2-AR stimulation on the performance of an isolated heart in rats with a model of myocardial infarction.
To study the mechanisms of MI, experiments were carried out according to the classical technique of H. Selye - ligation of the anterior branch of the left coronary artery and perfusion of a Langendorff heart with a model of myocardial infarction. We studied the parameters of myocardial activity by changes in heart rate, as well as the left
ventricle pressure (LVP), and the CF (dp/dtmax)/(dp/dtmin) of the left ventricle. Coronary dilator activity was assessed by measuring the outflow of the perfusion solution through the coronary arteries. The amplitude of the left ventricle's pressure wave after application of the α2-AR agonist clonidine hydrochloride at a concentration of 10-6 M to the perfused solution increased by 44% (p≤0.05) from the initial values. The rate of contraction and the
rate of relaxation of the left ventricular myocardium also increased by 20% (p≤0.05) and 37% (p≤0.05), respectively. The activation of α2-AR in adult rats' isolated hearts with a model of myocardial infarction caused a decrease in heart rate by 18% (p≤0.05) and CF by 2% (p≤0.05). |
| Ключевые слова |
Model Myocardial infarction; α2-adrenoreceptors; Isolated heart; Rat |
| Название журнала |
Journal of Chemical Health Risks
|
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https://repository.kpfu.ru/?p_id=253398 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Купцова Анна Михайловна |
ru_RU |
| dc.contributor.author |
Хабибрахманов Инсаф Илхамович |
ru_RU |
| dc.contributor.author |
Бугров Роман Кутдусович |
ru_RU |
| dc.contributor.author |
Кобзарев Роман Сергеевич |
ru_RU |
| dc.date.accessioned |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2021 |
ru_RU |
| dc.identifier.citation |
Kuptsova A.M. Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction / A.M. Kuptsova, R.K. Bugrov, I.I. Khabibrakhmanov, R.S. Kobzarev, N.I. Ziyatdinova, T.L. Zefirov // Journal of Chemical Health Risks. 2021. - Vol. 11(2). pp. 129-134 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=253398 |
ru_RU |
| dc.description.abstract |
Journal of Chemical Health Risks |
ru_RU |
| dc.description.abstract |
Chronic adrenergic and angiotensin-energic stimulation of the heart muscle is one of the main causes of the onset and development of heart failure. α2-AR is widespread in the cardiovascular system and can be further applied and introduced into the heart's regenerative cell therapy. This study's objective was to study the effect of α2-AR stimulation on the performance of an isolated heart in rats with a model of myocardial infarction.
To study the mechanisms of MI, experiments were carried out according to the classical technique of H. Selye - ligation of the anterior branch of the left coronary artery and perfusion of a Langendorff heart with a model of myocardial infarction. We studied the parameters of myocardial activity by changes in heart rate, as well as the left
ventricle pressure (LVP), and the CF (dp/dtmax)/(dp/dtmin) of the left ventricle. Coronary dilator activity was assessed by measuring the outflow of the perfusion solution through the coronary arteries. The amplitude of the left ventricle's pressure wave after application of the α2-AR agonist clonidine hydrochloride at a concentration of 10-6 M to the perfused solution increased by 44% (p≤0.05) from the initial values. The rate of contraction and the
rate of relaxation of the left ventricular myocardium also increased by 20% (p≤0.05) and 37% (p≤0.05), respectively. The activation of α2-AR in adult rats' isolated hearts with a model of myocardial infarction caused a decrease in heart rate by 18% (p≤0.05) and CF by 2% (p≤0.05). |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Role of A2-adrenoceptors in Rat Heart with the Model of myocardial Infarction |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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