КФУ. Карточка публикации. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy

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DISRUPTING TUMOR ONSET AND GROWTH VIA SELECTIVE CELL TAGGING (SECT) THERAPY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Язык

английский

Авторы, сотрудники КФУ

Курбангалиева Альмира Рафаэловна, автор

Насибуллин Игорь Олегович, автор

Танака Кацунори , автор

Другие авторы

Nakao Yoichi , автор

Onoe Hirotaka , автор

Tahara Tsuyoshi , автор

Tsubokura Kazuki , автор

Urano Sayaka , автор

Vong Kenward , автор

Watanabe Yasuyoshi , автор

Библиографическое описание на языке оригинала

Vong, K. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy / K. Vong, T. Tahara, S. Urano, I. Nasibullin, K. Tsubokura, Y. Nakao, A. Kurbangalieva, H. Onoe, Y. Watanabe, K. Tanaka // Sci. Adv. – 2021. – V. 7, № 17. – Art. № eabg4038.

Аннотация

This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)–based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic–Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications.

Ключевые слова

cell tagging (SeCT) therapy, glycosylated artificial metalloenzyme, protein labeling,

Название журнала

Science advances

URL

https://www.science.org/doi/10.1126/sciadv.abg4038

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https://repository.kpfu.ru/?p_id=253584

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Курбангалиева Альмира Рафаэловна	ru_RU
dc.contributor.author	Насибуллин Игорь Олегович	ru_RU
dc.contributor.author	Танака Кацунори	ru_RU
dc.contributor.author	Nakao Yoichi	ru_RU
dc.contributor.author	Onoe Hirotaka	ru_RU
dc.contributor.author	Tahara Tsuyoshi	ru_RU
dc.contributor.author	Tsubokura Kazuki	ru_RU
dc.contributor.author	Urano Sayaka	ru_RU
dc.contributor.author	Vong Kenward	ru_RU
dc.contributor.author	Watanabe Yasuyoshi	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Vong, K. Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy / K. Vong, T. Tahara, S. Urano, I. Nasibullin, K. Tsubokura, Y. Nakao, A. Kurbangalieva, H. Onoe, Y. Watanabe, K. Tanaka // Sci. Adv. – 2021. – V. 7, № 17. – Art. № eabg4038.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=253584	ru_RU
dc.description.abstract	Science advances	ru_RU
dc.description.abstract	This study presents the early framework of selective cell tagging (SeCT) therapy, which is the concept of preferentially labeling specific cells in vivo with chemical moieties that can elicit a therapeutic response. Using glycosylated artificial metalloenzyme (GArM)–based protein labeling, this study reports two separate functional strategies. In one approach, early tumor onset can be suppressed by tagging cancer cells in living mice with an integrin-blocking cyclic–Arg-Gly-Asp (cRGD) moiety, thereby disrupting cell adhesion onto the extracellular matrix. In another approach, tumor growth in mice can be reduced by tagging with a cytotoxic doxorubicin moiety. Subsequent cell death occurs following internalization and drug release. Overall, experiments have shown that mouse populations receiving the mixture of SeCT labeling reagents exhibited a significant delay/reduction in tumor onset and growth compared with controls. Highlighting its adaptability, this work represents a foundational step for further development of SeCT therapy and its potential therapeutic applications.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	cell tagging (SeCT) therapy	ru_RU
dc.subject	glycosylated artificial metalloenzyme	ru_RU
dc.subject	protein labeling	ru_RU
dc.subject		ru_RU
dc.title	Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU