| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2020 |
| Язык | русский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Купцова Анна Михайловна, автор
Леонова Алина Маратовна, автор
|
|
Леонова Алина Маратовна, автор
Миллер Арнольд Гейнрихович, автор
|
| Библиографическое описание на языке оригинала |
Kuptsova A.M. Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart / A.M. Kuptsova, A.M. Galieva, A.G. Miller, N.I. Ziyatdinova, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica. 2020. - Vol. 39, N.7. - pp.826-830. |
| Аннотация |
Adrenergic receptors agonists are widely used to treat car- diovascular diseases. All 3 subtypes of α2-adrenergic recep- tors (α2-AR) have been found in the human heart using the polymerase chain reaction. Radioligand test and immunob- lotting revealed α2-AR in the myocardium of normotensive and also spontaneously hypertensive rats. The evidence demonstrated the interaction of α2-AR and If in the relief of mechanical and thermal pain. The α2-AR agonist, clonidine, by inhibiting HCN channels, causes a strong bradycardic ef- fect. The objective of this research is to study the effect of the activation of α2-AR in the presence of the blockade of If with ZD7288, on the parameters of the isolated rat heart after the formation of adrenergic regulation of the heart. Experi- ments on isolated hearts were performed ex vivo, using the Langendorff-isolated heart preparation. During the study, the coronary flow (CF), heart rate (HR), pressure wave amplitude (PWA), maximum wave rise rate (dP/dtmax), maximum wave drop rate (dP/dtmin) were studied. The findings demonstrate a role of α2-AR and If in the adrenergic regulation mechanisms of the function of an isolated heart of 6-week-old rats, since they showed that the blockade of If with ZD7288, caused an increase in heart inotropy, as well as multidirectional effects on the rhythm and blood flow of the isolated rat heart after the formation of adrenergic innervation. |
| Ключевые слова |
α2-adrenoreceptors, If-currents, isolated heart, rat. |
| Название журнала |
Archivos Venezolanos de Farmacología y Terapéutica
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=253700 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Купцова Анна Михайловна |
ru_RU |
| dc.contributor.author |
Леонова Алина Маратовна |
ru_RU |
| dc.contributor.author |
Леонова Алина Маратовна |
ru_RU |
| dc.contributor.author |
Миллер Арнольд Гейнрихович |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Kuptsova A.M. Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart / A.M. Kuptsova, A.M. Galieva, A.G. Miller, N.I. Ziyatdinova, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica. 2020. - Vol. 39, N.7. - pp.826-830. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=253700 |
ru_RU |
| dc.description.abstract |
Archivos Venezolanos de Farmacología y Terapéutica |
ru_RU |
| dc.description.abstract |
Adrenergic receptors agonists are widely used to treat car- diovascular diseases. All 3 subtypes of α2-adrenergic recep- tors (α2-AR) have been found in the human heart using the polymerase chain reaction. Radioligand test and immunob- lotting revealed α2-AR in the myocardium of normotensive and also spontaneously hypertensive rats. The evidence demonstrated the interaction of α2-AR and If in the relief of mechanical and thermal pain. The α2-AR agonist, clonidine, by inhibiting HCN channels, causes a strong bradycardic ef- fect. The objective of this research is to study the effect of the activation of α2-AR in the presence of the blockade of If with ZD7288, on the parameters of the isolated rat heart after the formation of adrenergic regulation of the heart. Experi- ments on isolated hearts were performed ex vivo, using the Langendorff-isolated heart preparation. During the study, the coronary flow (CF), heart rate (HR), pressure wave amplitude (PWA), maximum wave rise rate (dP/dtmax), maximum wave drop rate (dP/dtmin) were studied. The findings demonstrate a role of α2-AR and If in the adrenergic regulation mechanisms of the function of an isolated heart of 6-week-old rats, since they showed that the blockade of If with ZD7288, caused an increase in heart inotropy, as well as multidirectional effects on the rhythm and blood flow of the isolated rat heart after the formation of adrenergic innervation. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
α2-adrenoreceptors |
ru_RU |
| dc.subject |
If-currents |
ru_RU |
| dc.subject |
isolated heart |
ru_RU |
| dc.subject |
rat. |
ru_RU |
| dc.title |
Effect of α2-Adrenoreceptors stimulation after blockade of the current activated by hyperpolarization, if, in 6-week-old rat's isolated heart |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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