| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2020 |
| Язык | русский |
|
Зефиров Тимур Львович, автор
Зиятдинова Нафиса Ильгизовна, автор
Купцова Анна Михайловна, автор
Хабибрахманов Инсаф Илхамович, автор
|
|
Бугров Роман Кутдусович, автор
|
| Библиографическое описание на языке оригинала |
Bugrov R.K. Influence of If-current blockade on rat heart contractility with a model of myocardial infarction / R.K. Bugrov, A.M. Kuptsova, I.I.Khabibrakhmanov, N.I. Ziyatdinova, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica. - 2020. - Vol.39, N. 7. - pp. 817-821. |
| Аннотация |
Hyperpolarization -activated cyclic nucleotide- dependent channels (HCN) are widespread throughout the body and participate in various physiological processes, the most im- portant of which is the generation of spontaneous electrical activity in the heart and the regulation of synaptic transmis- sion in the brain. The physiological role of HCN channels in the working healthy myocardium is still the subject of ongoing research. The objective of this research is to study the ef- fect of If blockade with ZD7288, on heart inotropy in rats with a modeled myocardial infarction. Two methods were used, the classical model of reproduction of myocardial infarction in experimental animals, developed in 1960 by Selye, and the isolated heart technique according to Langendorff. The peculiarities of the inotropic function of an isolated heart with a model of myocardial infarction during current blockade ac- tivated by hyperpolarization were evaluated. The If blocker, ZD7288, at concentrations of 10-9 M and 10-7 M, led to an increase in the pressure wave amplitude by 43% and 40% (p≤0.05), respectively, and at a concentration of 10-5 M, to a decrease in the pressure wave amplitude by 49% according to Langendorff' technique. The value of the maximum rate of rising of the pressure wave (dP/dtmax) increased during per- fusion of ZD7288 at concentrations of 10-9 M and 10-7 M by 31%, and the maximum rate of drop of the pressure wave (dP/dtmin) increased by 27% and 32%, respectively. The ad- dition of the drug to the solution (10-5 M) caused a decrease in dP/dtmax by 44%, and dP/dtmin by 41%. Thus, it can be con- cluded that impaired coronary blood supply is not the only factor in the pathogenesis of the disease typical of human myocardial infarction. |
| Ключевые слова |
a model of myocardial infarction, hyperpolariza- tion-activated currents, isolated heart, rat. |
| Название журнала |
Archivos Venezolanos de Farmacología y Terapéutica
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=253701 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Зефиров Тимур Львович |
ru_RU |
| dc.contributor.author |
Зиятдинова Нафиса Ильгизовна |
ru_RU |
| dc.contributor.author |
Купцова Анна Михайловна |
ru_RU |
| dc.contributor.author |
Хабибрахманов Инсаф Илхамович |
ru_RU |
| dc.contributor.author |
Бугров Роман Кутдусович |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Bugrov R.K. Influence of If-current blockade on rat heart contractility with a model of myocardial infarction / R.K. Bugrov, A.M. Kuptsova, I.I.Khabibrakhmanov, N.I. Ziyatdinova, T.L. Zefirov // Archivos Venezolanos de Farmacología y Terapéutica. - 2020. - Vol.39, N. 7. - pp. 817-821. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=253701 |
ru_RU |
| dc.description.abstract |
Archivos Venezolanos de Farmacología y Terapéutica |
ru_RU |
| dc.description.abstract |
Hyperpolarization -activated cyclic nucleotide- dependent channels (HCN) are widespread throughout the body and participate in various physiological processes, the most im- portant of which is the generation of spontaneous electrical activity in the heart and the regulation of synaptic transmis- sion in the brain. The physiological role of HCN channels in the working healthy myocardium is still the subject of ongoing research. The objective of this research is to study the ef- fect of If blockade with ZD7288, on heart inotropy in rats with a modeled myocardial infarction. Two methods were used, the classical model of reproduction of myocardial infarction in experimental animals, developed in 1960 by Selye, and the isolated heart technique according to Langendorff. The peculiarities of the inotropic function of an isolated heart with a model of myocardial infarction during current blockade ac- tivated by hyperpolarization were evaluated. The If blocker, ZD7288, at concentrations of 10-9 M and 10-7 M, led to an increase in the pressure wave amplitude by 43% and 40% (p≤0.05), respectively, and at a concentration of 10-5 M, to a decrease in the pressure wave amplitude by 49% according to Langendorff' technique. The value of the maximum rate of rising of the pressure wave (dP/dtmax) increased during per- fusion of ZD7288 at concentrations of 10-9 M and 10-7 M by 31%, and the maximum rate of drop of the pressure wave (dP/dtmin) increased by 27% and 32%, respectively. The ad- dition of the drug to the solution (10-5 M) caused a decrease in dP/dtmax by 44%, and dP/dtmin by 41%. Thus, it can be con- cluded that impaired coronary blood supply is not the only factor in the pathogenesis of the disease typical of human myocardial infarction. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
a model of myocardial infarction |
ru_RU |
| dc.subject |
hyperpolariza- tion-activated currents |
ru_RU |
| dc.subject |
isolated heart |
ru_RU |
| dc.subject |
rat. |
ru_RU |
| dc.title |
Influence of If-current blockade on rat heart contractility with a model of myocardial infarction |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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