КФУ. Карточка публикации. Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties

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RATIONAL DESIGN 2-HYDROXYPROPYLPHOSPHONIUM SALTS AS CANCER CELL MITOCHONDRIA-TARGETED VECTORS: SYNTHESIS, STRUCTURE, AND BIOLOGICAL PROPERTIES

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Язык

английский

Авторы, сотрудники КФУ

Титов Евгений Андреевич, автор

Библиографическое описание на языке оригинала

Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties / Mironov V.F., Nemtarev A.V., Tsepaeva O.V., Dimukhametov M.N., Litvinov I.A., Voloshina A.D., Pashirova T.N., Titov E.A., Lyubina A.P., Amerhanova S.K., Gubaidullin A.T., Islamov D.R. // Molecules. MDPI AG - 2021. - V. 26, N. 21, P. 6350

Аннотация

Molecules

Ключевые слова

phosphonium salt; P?C bond formation; oxirane; glycidyl ether; triphenylphosphine; addition reaction; nucleophilic substitution

Название журнала

Molecules

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https://repository.kpfu.ru/?p_id=257826

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Титов Евгений Андреевич	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties / Mironov V.F., Nemtarev A.V., Tsepaeva O.V., Dimukhametov M.N., Litvinov I.A., Voloshina A.D., Pashirova T.N., Titov E.A., Lyubina A.P., Amerhanova S.K., Gubaidullin A.T., Islamov D.R. // Molecules. MDPI AG - 2021. - V. 26, N. 21, P. 6350	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=257826	ru_RU
dc.description.abstract	Molecules	ru_RU
dc.description.abstract	It has been shown for a wide range of epoxy compounds that their interaction with tri- phenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2- hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, al- kylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride etherate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypro- pyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolecular struc- ture of the obtained phosphonium salts was established, and their high antitumor activity was re- vealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phos- phonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailability and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU