Казанский (Приволжский) федеральный университет, КФУ
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ADAMANTYL SUBSTITUTED PYRIDOXINE DERIVATIVES
Форма представленияСтатьи в российских журналах и сборниках
Год публикации2019
Языканглийский
  • Хазиев Раиль Маратович, автор
  • Библиографическое описание на языке оригинала Khaziev, R. Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives / R. Khaziev, N. Shtyrlin, R. Pavelyev, R. Nigmatullin, R. Gabbasova, D. Grishaev, A. Shtro, A. Galochkina, Y. Nikolaeva, T. Vinogradova, O. Manicheva, M. Dogonadze, O. Gnezdilov, E. Sokolovich, P. Yablonskiy, K. Balakin, Yu. Shtyrlin // Letters in Drug Design & Discovery. – 2019. – V. 16, N. 2. – P. 1360-1369
    Аннотация Adamantane derivatives possess multiple pharmacological activities such as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of medicinal chemists in adamantane compounds is due to their unique spatial structure, high lipophilicity, and carbon cage rigidity. As a result, these molecules can easily penetrate biological lipid membranes and often have unique target-specific activity profile. Another pharmacophore studied in this work is pyridoxine (vitamin B6). Pyridoxine plays highly important roles in living cells as a key cofactor of many enzymes. On the other hand, its molecular scaffold is a valuable structural platform which has led to the development of several launched drugs (Pyritinol, Pirisudanol, Cycletanine, Mangafodipir) and a wide number of preclinical and clinical drug candidates
    Ключевые слова Pyridoxine, adamantane derivatives, antimycobacterial activity, antiviral activity, M. tuberculosis, dipharmacophore molecules
    Название журнала LETTERS IN DRUG DESIGN & DISCOVERY
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