| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2019 |
| Язык | английский |
|
Хазиев Раиль Маратович, автор
|
| Библиографическое описание на языке оригинала |
Khaziev, R. Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives / R. Khaziev, N. Shtyrlin, R. Pavelyev, R. Nigmatullin, R. Gabbasova, D. Grishaev, A. Shtro, A. Galochkina, Y. Nikolaeva, T. Vinogradova, O. Manicheva, M. Dogonadze, O. Gnezdilov, E. Sokolovich, P. Yablonskiy, K. Balakin, Yu. Shtyrlin // Letters in Drug Design & Discovery. – 2019. – V. 16, N. 2. – P. 1360-1369 |
| Аннотация |
Adamantane derivatives possess multiple pharmacological activities such
as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of
medicinal chemists in adamantane compounds is due to their unique spatial structure, high lipophilicity,
and carbon cage rigidity. As a result, these molecules can easily penetrate biological lipid
membranes and often have unique target-specific activity profile. Another pharmacophore studied in
this work is pyridoxine (vitamin B6). Pyridoxine plays highly important roles in living cells as a key
cofactor of many enzymes. On the other hand, its molecular scaffold is a valuable structural platform
which has led to the development of several launched drugs (Pyritinol, Pirisudanol, Cycletanine,
Mangafodipir) and a wide number of preclinical and clinical drug candidates |
| Ключевые слова |
Pyridoxine, adamantane derivatives, antimycobacterial activity, antiviral activity, M. tuberculosis, dipharmacophore
molecules |
| Название журнала |
LETTERS IN DRUG DESIGN & DISCOVERY
|
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=257993 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Хазиев Раиль Маратович |
ru_RU |
| dc.date.accessioned |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2019-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2019 |
ru_RU |
| dc.identifier.citation |
Khaziev, R. Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives / R. Khaziev, N. Shtyrlin, R. Pavelyev, R. Nigmatullin, R. Gabbasova, D. Grishaev, A. Shtro, A. Galochkina, Y. Nikolaeva, T. Vinogradova, O. Manicheva, M. Dogonadze, O. Gnezdilov, E. Sokolovich, P. Yablonskiy, K. Balakin, Yu. Shtyrlin // Letters in Drug Design & Discovery. – 2019. – V. 16, N. 2. – P. 1360-1369 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=257993 |
ru_RU |
| dc.description.abstract |
LETTERS IN DRUG DESIGN & DISCOVERY |
ru_RU |
| dc.description.abstract |
Adamantane derivatives possess multiple pharmacological activities such
as antiviral, anticancer, antimycobacterial, antidiabetic, antiparkinsonian and others. The interest of
medicinal chemists in adamantane compounds is due to their unique spatial structure, high lipophilicity,
and carbon cage rigidity. As a result, these molecules can easily penetrate biological lipid
membranes and often have unique target-specific activity profile. Another pharmacophore studied in
this work is pyridoxine (vitamin B6). Pyridoxine plays highly important roles in living cells as a key
cofactor of many enzymes. On the other hand, its molecular scaffold is a valuable structural platform
which has led to the development of several launched drugs (Pyritinol, Pirisudanol, Cycletanine,
Mangafodipir) and a wide number of preclinical and clinical drug candidates |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Pyridoxine |
ru_RU |
| dc.subject |
adamantane derivatives |
ru_RU |
| dc.subject |
antimycobacterial activity |
ru_RU |
| dc.subject |
antiviral activity |
ru_RU |
| dc.subject |
M. tuberculosis |
ru_RU |
| dc.subject |
dipharmacophore
molecules |
ru_RU |
| dc.title |
Synthesis and antimicrobial activity of adamantyl substituted pyridoxine derivatives |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
