КФУ. Карточка публикации. Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy

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EXPOSING HIDDEN CONFORMATIONS OF CARBAMAZEPINE APPEARING DUE TO INTERACTION WITH THE SOLID PHASE BY 2D 1H-15N HMBC NMR SPECTROSCOPY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2021

Язык

английский

Авторы, сотрудники КФУ

Ефимов Сергей Владимирович, автор

Ходов Илья Анатольевич, автор

Библиографическое описание на языке оригинала

Khodov I, Efimov S, Krestyaninov M, Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy//Journal of Pharmaceutical Sciences. - 2021. - Vol. 110, P 1533-1539

Аннотация

Two-dimensional 1H-15N HMBC NMR spectra of the well-known anticonvulsant carbamazepine dissolved in different organic solvents, recorded on an NMR spectrometer prove the existence of hidden conformers in saturated solutions. Obtained conformer distribution arises due to the presence of the solid phase in saturated solution. A weak influence of ring currents was revealed for different molecular conformations of carbamazepine dissolved in a saturated solution, which provides a simple approach to discovering hidden conformations. Hidden conformers were found in three different solvents: dimethyl sulfoxide, chloroform, and dichloromethane.

Ключевые слова

Drug design; Nuclear magnetic resonance (NMR) spectroscopy; Polymorph(s); Spectroscopy; Structure

Название журнала

Journal of Pharmaceutical Sciences

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099629931&doi=10.1016%2fj.xphs.2021.01.001&partnerID=40&md5=06206c3599cb6622ed26a49075941e61

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https://repository.kpfu.ru/?p_id=258027

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ефимов Сергей Владимирович	ru_RU
dc.contributor.author	Ходов Илья Анатольевич	ru_RU
dc.date.accessioned	2021-01-01T00:00:00Z	ru_RU
dc.date.available	2021-01-01T00:00:00Z	ru_RU
dc.date.issued	2021	ru_RU
dc.identifier.citation	Khodov I, Efimov S, Krestyaninov M, Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy//Journal of Pharmaceutical Sciences. - 2021. - Vol. 110, P 1533-1539	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=258027	ru_RU
dc.description.abstract	Journal of Pharmaceutical Sciences	ru_RU
dc.description.abstract	Two-dimensional 1H-15N HMBC NMR spectra of the well-known anticonvulsant carbamazepine dissolved in different organic solvents, recorded on an NMR spectrometer prove the existence of hidden conformers in saturated solutions. Obtained conformer distribution arises due to the presence of the solid phase in saturated solution. A weak influence of ring currents was revealed for different molecular conformations of carbamazepine dissolved in a saturated solution, which provides a simple approach to discovering hidden conformations. Hidden conformers were found in three different solvents: dimethyl sulfoxide, chloroform, and dichloromethane.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU