| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2021 |
| Язык | английский |
|
Абрамова Зинаида Ивановна, автор
Биктагирова Эльнара Маулетовна, автор
|
|
Alsoulaiman Lamak , автор
|
| Библиографическое описание на языке оригинала |
Alsoulaiman L. The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer / L. Alsoulaiman, E. Biktagirova, Z. Abramova//CELL DEATH DISCOVERY. - 2021. - Vol.7, Is.SUPPL 1. - P.1-1. |
| Аннотация |
Epithelial ovarian cancer is one of the most lethal oncogynecological diseases. Recent researches showed that autophagy induction contributes to the development of the resistance against anticancer drugs. In this work, we evaluated the contribution of the autophagy to cisplatin resistance in the ovarian cancer cell line OVCR8. Atg5 protein plays a critical role in the initiation and elongation stages of autophagy. Effective knockout for ATG5 blocks autophagy induction in the ovarian cancer cell lines, which is confirmed by the lower expression level of the LC-II.
We are hypothesizing that in ovarian cancer cells, p62 level is regulated by uncharacterized signaling cascade that senses level of the autophagy. The exact mechanism of this process in autophagy- missing cells is not clear. In addition, in Atg5-knockouted cells, Bcl2 levels were higher than wild-type (p-value < 0.05*) and high level of Bcl2 inhibits apoptosis, and contributes to the resistance to chemotherapeutic drugs, which is consistent with earlier published Results. Autophagy is a promising therapeutic target and characterization of autophagy-mediated chemotherapeutic resistance will pave the way to better treatment of the ovarian cancers. |
| Ключевые слова |
autophagy, resistance, cisplatin, ovarian cancer |
| Название журнала |
CELL DEATH DISCOVERY
|
| URL |
https://www.nature.com/articles/s41420-021-00587-w |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=259228 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абрамова Зинаида Ивановна |
ru_RU |
| dc.contributor.author |
Биктагирова Эльнара Маулетовна |
ru_RU |
| dc.contributor.author |
Alsoulaiman Lamak |
ru_RU |
| dc.date.accessioned |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2021-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2021 |
ru_RU |
| dc.identifier.citation |
Alsoulaiman L. The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer / L. Alsoulaiman, E. Biktagirova, Z. Abramova//CELL DEATH DISCOVERY. - 2021. - Vol.7, Is.SUPPL 1. - P.1-1. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=259228 |
ru_RU |
| dc.description.abstract |
CELL DEATH DISCOVERY |
ru_RU |
| dc.description.abstract |
Epithelial ovarian cancer is one of the most lethal oncogynecological diseases. Recent researches showed that autophagy induction contributes to the development of the resistance against anticancer drugs. In this work, we evaluated the contribution of the autophagy to cisplatin resistance in the ovarian cancer cell line OVCR8. Atg5 protein plays a critical role in the initiation and elongation stages of autophagy. Effective knockout for ATG5 blocks autophagy induction in the ovarian cancer cell lines, which is confirmed by the lower expression level of the LC-II.
We are hypothesizing that in ovarian cancer cells, p62 level is regulated by uncharacterized signaling cascade that senses level of the autophagy. The exact mechanism of this process in autophagy- missing cells is not clear. In addition, in Atg5-knockouted cells, Bcl2 levels were higher than wild-type (p-value < 0.05*) and high level of Bcl2 inhibits apoptosis, and contributes to the resistance to chemotherapeutic drugs, which is consistent with earlier published Results. Autophagy is a promising therapeutic target and characterization of autophagy-mediated chemotherapeutic resistance will pave the way to better treatment of the ovarian cancers. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
autophagy |
ru_RU |
| dc.subject |
resistance |
ru_RU |
| dc.subject |
cisplatin |
ru_RU |
| dc.subject |
ovarian cancer |
ru_RU |
| dc.title |
The role of autophagy in chemotherapy resistance of cisplatin in ovarian cancer |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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