Форма представления | Статьи в зарубежных журналах и сборниках |
Год публикации | 2021 |
Язык | английский |
|
Гильфанов Ильмир Рафисович, автор
Ефимов Сергей Владимирович, автор
Каюмов Айрат Рашитович, автор
Клочков Владимир Васильевич, автор
Остолоповская Ольга Вячеславовна, автор
Павельев Роман Сергеевич, автор
Ходов Илья Анатольевич, автор
|
Библиографическое описание на языке оригинала |
Guseva G.B, Antina E.V, Berezin M.B, Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking//Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. - 2021. - Vol., Is.. - Art. №120638. |
Аннотация |
This paper is devoted to the design of a fluorescent probe based on meso-carboxysubstituted-BODIPY with a thioterpene fragment. The functional replacement of the methoxy group in the BODIPY molecule on a thioterpene fragment was carried out in order to find out the antiplatelet and anticoagulant action mechanisms of thioterpenoids and to assess the membrane and receptor factors contributions. The molecular structure of the conjugate was confirmed via UV/vis-, NMR- and MS-spectra. It is found that the probe is a high fluorescence quantum yield (to ∼ 100%) in the blue-green region at 509–516 nm. Molecular docking of all studied molecules showed that the BODIPY with terpenoid conjugation is an excellent way to increase their affinity to platelet receptor P2Y12. |
Ключевые слова |
BODIPY, Thioterpenoid, Conjugate, Structure, Spectral properties, Molecular docking |
Название журнала |
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
|
URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120326609&doi=10.1016%2fj.saa.2021.120638&partnerID=40&md5=7f88ebdf9d635e51e5b94a55ea1523e0 |
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https://repository.kpfu.ru/?p_id=260708 |
Полная запись метаданных |
Поле DC |
Значение |
Язык |
dc.contributor.author |
Гильфанов Ильмир Рафисович |
ru_RU |
dc.contributor.author |
Ефимов Сергей Владимирович |
ru_RU |
dc.contributor.author |
Каюмов Айрат Рашитович |
ru_RU |
dc.contributor.author |
Клочков Владимир Васильевич |
ru_RU |
dc.contributor.author |
Остолоповская Ольга Вячеславовна |
ru_RU |
dc.contributor.author |
Павельев Роман Сергеевич |
ru_RU |
dc.contributor.author |
Ходов Илья Анатольевич |
ru_RU |
dc.date.accessioned |
2021-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2021-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2021 |
ru_RU |
dc.identifier.citation |
Guseva G.B, Antina E.V, Berezin M.B, Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking//Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. - 2021. - Vol., Is.. - Art. №120638. |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/?p_id=260708 |
ru_RU |
dc.description.abstract |
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy |
ru_RU |
dc.description.abstract |
This paper is devoted to the design of a fluorescent probe based on meso-carboxysubstituted-BODIPY with a thioterpene fragment. The functional replacement of the methoxy group in the BODIPY molecule on a thioterpene fragment was carried out in order to find out the antiplatelet and anticoagulant action mechanisms of thioterpenoids and to assess the membrane and receptor factors contributions. The molecular structure of the conjugate was confirmed via UV/vis-, NMR- and MS-spectra. It is found that the probe is a high fluorescence quantum yield (to ∼ 100%) in the blue-green region at 509–516 nm. Molecular docking of all studied molecules showed that the BODIPY with terpenoid conjugation is an excellent way to increase their affinity to platelet receptor P2Y12. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
BODIPY |
ru_RU |
dc.subject |
Thioterpenoid |
ru_RU |
dc.subject |
Conjugate |
ru_RU |
dc.subject |
Structure |
ru_RU |
dc.subject |
Spectral properties |
ru_RU |
dc.subject |
Molecular docking |
ru_RU |
dc.title |
Conjugate of meso-carboxysubstituted-BODIPY with thioterpenoid as an effective fluorescent probe: Synthesis, structure, spectral characteristics, and molecular docking |
ru_RU |
dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
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