Казанский (Приволжский) федеральный университет, КФУ
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DELIMITATION OF THE TICK-BORNE FLAVIVIRUSES. RESOLVING THE TICK-BORNE ENCEPHALITIS VIRUS AND LOUPING-ILL VIRUS PARAPHYLETIC TAXA
Форма представленияСтатьи в зарубежных журналах и сборниках
Год публикации2022
Языканглийский
  • Ткачев Сергей Евгеньевич, автор
  • Библиографическое описание на языке оригинала Bondaryuk et al., 2022. Delimitation of the tick-borne flaviviruses. Resolving the tick-borne encephalitis virus and louping-ill virus paraphyletic taxa // Molecular Phylogenetics and Evolution, ISSN: 1055-7903, Vol: 169, Page: 107411
    Аннотация he tick-borne flavivirus (TBFV) group contains at least 12 members where five of them are important pathogens of humans inducing diseases with varying severity (from mild fever forms to acute encephalitis). The taxonomy structure of TBFV is not fully clarified at present. In particular, there is a number of paraphyletic issues of tick-borne encephalitis virus (TBEV) and louping-ill virus (LIV). In this study, we aimed to apply different bioinformatic approaches to analyze all available complete genome amino acid sequences to delineate TBFV members at the species level. Results showed that the European subtype of TBEV (TBEV-E) is a distinct species unit. LIV, in turn, should be separated into two species. Additional analysis of TBEV and LIV antigenic determinant diversity also demonstrate that TBEV-E and LIV are significantly different both from each other and from the other TBEV subtypes. The analysis of available literature provided data on other virus phenotypic particularities that supported our hypothesis. So, within the TBEV + LIV paraphyletic group, we offer to assign four species to get a more accurate understanding of the TBFV interspecies structure according to the modern monophyletic conception.
    Ключевые слова TBFV, Species delimitation, Genomics, Phylogenetics
    Название журнала Molecular Phylogenetics and Evolution
    URL https://www.sciencedirect.com/science/article/abs/pii/S1055790322000240?via%3Dihub
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