| Форма представления | Тезисы и материалы конференций в зарубежных журналах и сборниках |
| Год публикации | 2022 |
| Язык | русский |
|
Абрамова Зинаида Ивановна, автор
|
| Библиографическое описание на языке оригинала |
Ibragimov B. 56ASM-0211 | Effect of N,N-?dimethylacetamide (DMAA) on the-viability of cell lines SKOV-3, OVCAR-8 during cryopreservation /B. Ibragimov, D. Nedorezova, V. Yugai, Z. Abramova / 56th Annual scientific meeting, 8–10 June 2022, Bari, Italy// Eur J Clin Invest.-2022.-V.52, Is.S1.- P.169-170, |
| Аннотация |
56th Annual scientific meeting |
| Ключевые слова |
N,N-?dimethylacetamide, SKOV-3, OVCAR-8, cryopreservation |
| Название журнала |
56th Annual scientific meeting
|
| URL |
https://onlinelibrary.wiley.com/doi/full/10.1111/eci.13796 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=267659 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абрамова Зинаида Ивановна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Ibragimov B. 56ASM-0211 | Effect of N,N-?dimethylacetamide (DMAA) on the-viability of cell lines SKOV-3, OVCAR-8 during cryopreservation /B. Ibragimov, D. Nedorezova, V. Yugai, Z. Abramova / 56th Annual scientific meeting, 8–10 June 2022, Bari, Italy// Eur J Clin Invest.-2022.-V.52, Is.S1.- P.169-170, |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=267659 |
ru_RU |
| dc.description.abstract |
56th Annual scientific meeting |
ru_RU |
| dc.description.abstract |
An improvement of technologies for controlling the processes of cell life activity under low-temperature conditions is one of the most important direc-tions in the development of modern medicine and biology. The methods of vitrification allow to preserve the cells structure and the subtle mechanisms of their functioning. Therefore, these methods provide the possibilities to use a tumor cell cryobiobank for monitoring the process of the patient's treatment. This work is aimed at analyzing the effect of cryoprotectants, such as N,N- dimethylacetamide (DMAA), glycerol, dimethyl sulfoxide (DMSO), and a mixture of glycerol- DMAA, on ovarian carcinoma cell lines (SKOV-3, OVCAR-8) by determining the IC50 of these cryopreservatives for these cell lines. The results can be used in the future for the development of cryoprotec-tive mixtures, which will be less toxic. Purpose of the work: to provide the comparative assess-ment of the effect of DMAA, glycerol, DMSO and a mix-ture of DMAA-glycerol solutions on the viability of cell lines SKOV- 3, OVCAR- 8.
Experimental data show that the concentration of half- maximal cell growth inhibition (IC50) of the mix-ture of DMAA and glycerol solutions was higher in both cell lines compared to the IC50 of the original solution. Accordingly, cells treated with this mixture had a higher viability.
The results indicate that cryoprotectants, which make cells less susceptible to cryodamage, reduce the intensity of cell vital processes. A mixture of cryoprotectants DMAA and glycerol has less toxicity than the original DMAA solution.
|
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
N |
ru_RU |
| dc.subject |
N-?dimethylacetamide |
ru_RU |
| dc.subject |
SKOV-3 |
ru_RU |
| dc.subject |
OVCAR-8 |
ru_RU |
| dc.subject |
cryopreservation |
ru_RU |
| dc.title |
Effect of N,N-?dimethylacetamide (DMAA) on the-viability of cell lines SKOV-3, OVCAR-8 during cryopreservation |
ru_RU |
| dc.type |
Тезисы и материалы конференций в зарубежных журналах и сборниках |
ru_RU |
|
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